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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Exp Eye Res. 2015 Aug 10;139:115–122. doi: 10.1016/j.exer.2015.08.004

Table 2.

Study-specific and meta-analysis results of CLU SNPs with exfoliation syndrome in the US and Israeli datasets

Minor allele frequency
US
 Israel
 Meta-analysis
SNP Minor allele XFS Controls XFS Controls OR (95%CI) Padj a Q b
rs3087554 G 0.18 0.18 0.16 0.15 1.01 (0.76-1.35) 0.63 0.90
crs2279590 A 0.35 0.32 0.36 0.35 1.04 (0.79-1.35) 0.56 0.99
rs9331931 C 0.30 0.27 0.28 0.31 1.08 (0.85-1.37) 0.45 0.30
rs11136000 T 0.37 0.36 0.37 0.38 1.01 (0.81-1.27) 0.71 0.82
rs9314349 G 0.36 0.37 0.32 0.28 1.01 (0.81-1.27) 0.77 0.43
rs569205 T 0.40 0.40 0.34 0.38 0.96 (0.77-1.20) 0.69 0.59
rs484377 C 0.44 0.46 0.46 0.47 0.94 (0.75-1.17) 0.53 0.97
rs492638 T 0.28 0.33 0.24 0.29 0.80 (0.63-1.03) 0.13 0.98

Abbreviation: XFS (exfoliation syndrome) refers to all exfoliation cases with and without glaucoma.

a

Logistic regression after adjustment for age and sex. The Bonferroni corrected significance level was set as 0.006 (0.05/8).

b

The heterogeneity between datasets was evaluated using the Cochran's Q statistic.

c

Imputed according to the phased haplotypes of HapMap reference CEU samples.