Table 1.
Mean (standard deviation) of discovery sample (GOLDN) and replication data (HAPI Heart).
| Discovery | Replication | |||||||
|---|---|---|---|---|---|---|---|---|
| GOLDN Study | HAPI Heart Study | |||||||
| Everyone (N=872) |
Men (N=429) | Women (N=443) |
Everyone (N=843) |
Men (N=453) |
Women (N=390) |
|||
| Age, yrs | 50.0 (16.2) | 50.0 (16.2) | 49.9 (16.2) | 44 (14) | 42 (14) | 45 (14) | ¶ | |
| Body Mass Index, kg/m2 | 28.5 (5.6) | 28.5 (4.6) | 28.5 (6.4) | 27 (4) | 26 (3) | 28 (5) | * | |
| Triglycerides, mg/dL | 139.4 (96.7) | 150.0 (107.5) | 129.0 (83.7) | ¶ | 69 (42) | 69 (40) | 69 (44) | |
| Phenotypes--Minimal model | ||||||||
| TG Uptake Slope | 0.18 (0.03) | 0.18 (0.03) | 0.18 (0.03) | * | 0.30 (0.00) | 0.30 (0.00) | 0.30 (0.00) | |
| TG Clearance Slope | −0.06 (0.05) | −0.06 (0.05) | −0.07 (0.05) | ¶ | −0.06 (0.08) | −0.05 (0.08) | −0.07 (0.07) | |
| TG Area Under the Curve | 31.1 (3.4) | 31.7 (3.3) | 30.5 (3.3) | * | 28.6 (2.9) | 28.8 (2.6) | 28.4 (3.2) | |
| TG Area Under the Increase | 2.5 (0.6) | 2.5 (0.6) | 2.4 (0.5) | * | 4.3 (0.29) | 4.3 (0.3) | 4.2 (0.3) | |
| Phenotypes—Adjusted for baseline | ||||||||
| TG model | ||||||||
| Uptake Slope | 0.19 (0.03) | 0.19 (0.03) | 0.18 (0.03) | 0.30 (0.00) | 0.30 (0.00) | 0.30 (0.00) | ||
| Clearance Slope | −0.07 (0.05) | −0.06 (0.05) | −0.07 (0.05) | ¶ | −0.06 (0.02) | −0.06 (0.02) | −0.05 (0.02) | |
| AUC | 28.0 (8.9) | 28.7 (8.8) | 27.3 (8.8) | 28.6 (2.6) | 28.4 (2.4) | 28.9 (2.9) | ||
| AUI | 2.5 (0.6) | 2.6 (0.6) | 2.5 (0.6) | 4.3 (0.05) | 4.3 (0.05) | 4.3 (0.06) | ||
*
p-value for difference between men and women (within each study) significant with p<0.0001
¶
p-value for difference between men and women (within each study) significant with p<0.005