Table 3.
Top SNPs Associated with Triglyceride Response to a high-fat meal adjusted for baseline TG Level in the GOLDN and HAPI Heart Studies.
| Phenotype | Discovery GOLDN (n=872) |
Replication HAPI Heart (n=843) |
Joint Meta-Analysis (GOLDN and HAPI, n=1,715) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AUC | Chr | Gene | Role | EA | EAF | Beta (SE) | p-value | Beta (SE) | p- value |
EA | EAF | Beta (SE) | p-value | Direction |
| rs10243693 | 7:68904887 | A | 0.3642 | 0.2788 (0.0506) | 3.50E-08 | −0.0966 (0.0637) | 0.1298 | A | 0.3392 | 0.1338 (0.0396) | 7.24E-04 | +− | ||
| rs6959964 | 7:68905738 | C | 0.3724 | 0.2574 (0.0502) | 2.86E-07 | −0.1194 (0.0645) | 0.0642 | C | 0.369 | 0.2574 (0.0502) | 2.88E-07 | +− | ||
| AUI | ||||||||||||||
| rs10866682 | 5:174036233 | C | 0.1039 | 0.4331 (0.0869) | 6.31E-07 | −0.0820 (0.0982) | 0.4044 | C | 0.1051 | 0.4331 (0.0869) | 6.31E-07 | +− | ||
| rs7712993 | 5:174037081 | A | 0.1039 | 0.4334 (0.0870) | 6.38E-07 | −0.0818 (0.0990) | 0.4091 | A | 0.1051 | 0.4334 (0.087) | 6.31E-07 | +− | ||
| Uptake Slope | ||||||||||||||
| rs10866682 | 5:174036233 | C | 0.1039 | 0.4271 (0.0861) | 6.99E-07 | −0.1538 (0.0967) | 0.1122 | C | 0.1052 | 0.4271 (0.0861) | 6.92E-07 | +− | ||
| rs7712993 | 5:174037081 | A | 0.1039 | 0.4274 (0.0862) | 7.05E-07 | −0.1550 (0.0975) | 0.1121 | A | 0.1051 | 0.4274 (0.0862) | 7.08E-07 | +− | ||
| Clearance Slope | ||||||||||||||
| none | ||||||||||||||