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ALAS catalytic reaction cycle. E, enzyme; G, glycine; SCoA, succinyl-coenzyme A; EGSCoA, Michaelis complex of enzyme with substrates; EQ, enzyme-bound quinonoid intermediate; EALAl, product-bound enzyme in closed conformation; EALA2, product-bound enzyme in open conformation; ALA, 5-aminolevulinate. The chemical nature of the reaction steps are noted above the arrows, while the enzyme conformation is noted below.
