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Effect of succinyl-CoA binding on circular dichroism spectra, far-UV region, of wild-type hALAS2 and XLPP variants. The spectra for (A) wild-type hALAS2, (B) delAT (C) delAGTG and (D) Q548X were recorded for the holoenzymes in the absence (solid lines) or presence of 50 μM succinyl-CoA (dashed lines). The concentrations of enzyme were 0.1 mg/mL in 20 mM phosphate buffer, pH 8.0.
