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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Cytokine. 2015 Aug 11;76(1):42–52. doi: 10.1016/j.cyto.2015.07.025

Figure 1. Model of immunity to disseminated C. tropicalis infection.

Figure 1

C. tropicalis is rapidly recognized by neutrophils and monocytes following invasive infection. Recognition by dectin-1 and other PRRs activates CARD9, which is crucial for host defense against C. tropicalis. CARD9 activation triggers the production of TNFα by both neutrophils and monocytes, which acts upon neutrophils to augment antifungal killing of C. tropicalis. TNFR = TNFα receptor.