Table 3. Summary of relative risks (RRs) for the association between treated maternal hypertensiona and congenital heart defects.
| Exposure | No. of studies | Summary RR (95 % CI) | Heterogeneity p value | Egger's test p value |
|---|---|---|---|---|
| Hypertension medications overall | 8 | 2.03 (1.54, 2.68) | 0.001 | 0.710 |
| ACE inhibitor | 4 | 2.12 (0.76, 5.93) | <0.001b | 0.556 |
| Beta-blockers | 3 | 2.10 (1.64, 2.70) | 0.037b | 0.461 |
| Calcium channel blockers | 3 | 1.16 (0.86, 1.55) | 0.347 | 0.232 |
a
Use of hypertension medication
b
When evidence of heterogeneity was observed, the effect from the random-effects model was reported