Least square means and standard error of the maximum score (WORMS max) and sum of WORMS lesions (WORMS sum) of menisci, cartilage and BMLs. Means are adjusted for age, sex, BMI, family history of knee replacement, history of knee surgery or injury, WOMAC pain, stiffness and disability (bilateral) hip and ankle pain (bilateral), average daily wear time of accelerometer. BMEP = bone marrow edema pattern.