Table 1.

Baseline characteristics by self-reported history of hot flashes

	Yes (n = 332)		No (n = 400)
Demographic characteristics and health habits	n	%	n	%	p-valuea
Age, years					<0.0001
45 to 49	177	53.3	303	75.7
50 to 54	155	46.7	97	24.3
Education					0.001
Some college or tech school or less	143	43.1	125	31.3
Graduated college or more	188	56.6	272	68.0
Race					0.18
White	209	63.0	275	68.8
Black	110	33.1	107	26.8
Other	13	3.9	16	4.0
Employed					0.51
Yes	259	78.0	320	80.0
No	72	21.7	79	19.8
Body mass index (kg/m2)					0.4
<25	128	38.6	163	40.7
25 to <30	87	26.2	114	28.5
≥30	117	35.2	123	30.8
Cigarette smoking					0.0002
Current	45	13.6	29	7.2
Former	133	40.1	129	32.3
Never	153	46.1	242	60.5
Alcohol use in past year					0.07
Yes, more than 1 drink per day	118	35.5	153	38.3
Yes, 1 drink or less per day	85	25.6	118	29.5
No	127	38.3	127	31.8
Leisure time activity compared to others of own age					0.07
More	112	33.7	144	36.0
As much	102	30.7	121	30.3
Less	116	34.9	128	32.0
Reproductive characteristics
Age at menarche					0.5
<10 years	26	7.8	22	5.5
11 or 12 years	126	38.0	160	40.0
13 or 14 years	140	42.2	159	39.8
≥15	39	11.7	53	13.3
Menopausal status					<0.0001
Pre-menopausal	146	44.0	334	83.5
Peri-menopausal	186	56.0	66	16.5
History of oral contraceptive use					0.07
Yes	290	87.3	331	82.7
No	41	12.3	69	17.3
Ever been pregnant					0.1
Yes	302	91.0	350	87.5
No	29	8.7	50	12.5
Number of pregnancies					0.4
Never been pregnant	29	8.7	50	12.5
1 or 2	104	31.3	131	32.7
3 or 4	136	41.0	150	37.5
≥5	62	18.7	69	17.3
Age at first birth					0.5
No live births	61	18.4	91	22.8
≤20 years	44	13.3	42	10.5
21 to 25 years	71	21.4	79	19.8
26 to 30 years	75	22.6	83	20.8
≥30 years	79	23.8	103	25.8
Health and medication use
Depressive symptoms					0.0002
Yes	85	25.6	59	14.8
No	236	71.1	329	82.3
Diabetes medication					0.1
Yes	18	5.4	12	3.0
No	313	94.3	387	96.8
Hypertension medication					0.04
Yes	59	17.8	49	12.3
No	272	81.9	350	87.5
Depression medication					0.3
Yes	43	13.0	41	10.3
No	288	86.7	358	89.5
Hormones and ovarian volume	GM	95% CL	GM	95% CL	p-valuea
Estradiol, pg/mL (n = 726)	43.2	(40.2, 46.3)	62.7	(58.9, 66.8)	<0.0001
Testosterone, ng/mL (n = 727)	0.28	(0.26, 0.30)	0.29	(0.27, 0.31)	0.3
Progesterone, ng/mL (n = 668)	0.54	(0.47, 0.64)	1.53	(1.33, 1.76)	<0.0001
Ovarian volume, cm3 (n = 628)	3.56	(3.29, 3.97)	4.49	(4.09, 3.70)	0.0001

GM = Geometric mean; 95% CL = 95% confidence limits

^aChi-square p-values for categorical variables; t-test p-values for continuous variables