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. Author manuscript; available in PMC: 2016 Sep 14.
Published in final edited form as: Cancer Cell. 2015 Sep 14;28(3):307–317. doi: 10.1016/j.ccell.2015.07.012

Figure 1. Evolutionary dynamics of the methylome and transcriptome in initial and recurrent glioma pairs.

Figure 1

(A) Unsupervised hierarchical clustering of the top 50% most variable CpG sites. Annotations of sample type, grade of recurrence, and patient identification numbers are provided. The lines beneath the patient identification numbers connect initial and recurrent tumors from the same patient that are not adjacent to each other.

(B) The average methylation change from initial low-grade tumor to recurrence at each CpG site measured in patients that do not (left) or do (right) undergo malignant progression to GBM (grade IV). Colored dots represent CpG sites that show significant hypomethylation (orange dots, total count provided) or hypermethylation (green dots, total count provided) at recurrence (p valueadjust < 0.05 and |Δβ| > 0.2).

(C) Average gene-level expression changes from initial to recurrence in patients that do not (left) or do (right) undergo malignant progression to GBM. Significantly differentially expressed genes are highlighted in green (down-regulated at recurrence, total count provided) and orange (up-regulated at recurrence, total count provided) (p value < 0.05 and |Δlog2FPKM| > 1).

See also Figure S1 and Tables S1 and S2.