Table 1.

Parameter Values for Studies of Four Diseases¹³ and Three Studies of Schizophrenia²⁶

	RA	CD	MI	T2D	SCZ ISC	SCZ PGC1	SCZ PGC2
n1	16,016	5,309	6,042	14,919	5,953	19,548	77,195
n2	12,078	6,785	4,861	4,862	5,120	5,120	5,120
m	82,390	91,388	89,808	75,912	84,882	93,093	103,125
${\sigma }_1^2$	0.18	0.44	0.48	0.49	–	–	0.30
π01	0.973	0.972	0.980	0.962	–	–	0.95
P1	0.248	0.394	0.491	0.416	0.423	0.477	0.425
P2	0.126	0.273	0.396	0.396	0.515	0.515	0.515
K1	0.01	0.01	0.06	0.08	0.01	0.01	0.01
K2	0.01	0.01	0.06	0.08	0.01	0.01	0.01

Abbreviations are as follows: RA, rheumatoid arthritis; CD, celiac disease; MI, myocardial infarction; T2D, type II diabetes; SCZ, schizophrenia; ISC, International Schizophrenia Consortium; PGC, Psychiatric Genomics Consortium. Values of ${\sigma }_1^2$ and π₀₁ for RA, CD, MI, and T2D were estimated by Stahl et al.¹³ and subsequently used in our simulations. Those for SCZ are an approximation based on estimates from several studies and methods (Table 5).