Table 2.

Application of AVENGEME to Simulated Data for Four Genetic Models Shown in Table 1

	Estimation of${\sigma }_1^2$, π01				Estimation of${\sigma }_1^2$, π01,${\sigma }_{12}$
RA	CD	MI	T2D	RA	CD	MI	T2D
True ${\sigma }_1^2$	0.180	0.440	0.480	0.490	0.180	0.440	0.480	0.490
Mean ${\hat{\sigma }}_1^2$	0.180	0.438	0.486	0.483	0.270	0.467	0.522	0.581
SD ${\hat{\sigma }}_1^2$	0.019	0.035	0.050	0.034	0.312	0.325	0.335	0.332
Coverage	0.95	0.89	0.91	0.93	0.97	0.95	0.99	0.99
True π01	0.973	0.972	0.980	0.962	0.958	0.972	0.979	0.961
Mean ${\hat{\pi }}_{01}$	0.972	0.972	0.979	0.961	0.968	0.972	0.979	0.957
SD ${\hat{\pi }}_{01}$	0.0054	0.0046	0.0040	0.0052	0.028	0.016	0.011	0.018
Coverage	0.94	0.85	0.88	0.90	0.98	0.95	0.98	0.98
True σ12	–	–	–	–	0.180	0.440	0.480	0.490
Mean ${\hat{\sigma }}_{12}$	–	–	–	–	0.190	0.442	0.491	0.509
SD ${\hat{\sigma }}_{12}$	–	–	–	–	0.034	0.048	0.061	0.072
Coverage	–	–	–	–	0.98	0.93	0.94	0.993

Mean and standard deviation of parameter estimates and coverage of 95% confidence interval are shown over 1,000 simulations. Monte Carlo error for the mean is SD/√1000 and for coverage of 0.95 is 0.007.