Table 3.

Comparison of AVENGEME Performance with Weighted and Unweighted Score with Nested or Disjoint Intervals

	Estimation of${\sigma }_1^2$, π01				Estimation of${\sigma }_1^2$, π01, σ12
Disjoint		Nested		Disjoint		Nested
W	U	W	U	W	U	W	U
Mean ${\hat{\sigma }}_1^2$	0.274	0.274	0.254	0.258	0.299	0.298	0.422	0.471
SD ${\hat{\sigma }}_1^2$	0.011	0.011	0.008	0.009	0.105	0.106	0.045	0.081
Coverage	0.36	0.37	0	0	0.94	0.93	0.01	0.20
Mean ${\hat{\pi }}_{01}$	0.950	0.950	0.951	0.950	0.946	0.946	0.941	0.933
SD ${\hat{\pi }}_{01}$	0.004	0.004	0.003	0.003	0.016	0.017	0.006	0.008
Coverage	0.93	0.93	0.80	0.78	0.95	0.94	0.37	0.14
Mean ${\hat{\sigma }}_{12}$	–	–	–	–	0.281	0.280	0.289	0.309
SD ${\hat{\sigma }}_{12}$	–	–	–	–	0.042	0.043	0.013	0.021
Coverage	–	–	–	–	0.91	0.91	0.69	0.85

The SCZ simulation model with ${\sigma }_1^2={\sigma }_{12}=0.3$, π₀₁ = 0.95 was used (see main text for full details). Mean and standard deviation of parameter estimates and coverage of 95% confidence interval are shown over 1,000 simulations. Monte Carlo error for the mean is SD/√1000 and for coverage of 0.95 is 0.007. Abbreviations are as follows: W, weighted; U, unweighted.