Table III.

Pain characteristics by endometriosis stage.^a

Characteristic	Stage I (n = 107)		Stage II (n = 27)		Stage III (n = 23)		Stage IV (n = 28)		P
Chronic/cyclic pain (n [%])
Chronic pelvic pain	45 (42.1)		14 (51.9)		12 (52.2)		11 (39.3)		0.64
Cyclic pelvic pain	53 (49.5)		11 (40.7)		12 (52.2)		15 (53.6)		0.78
Pain type and severityb (n [%]; mean ± SD)									P (n [%])	P (mean ± SD)
Dyspareunia
Vaginal pain with intercourse	63 (58.9)	2.7 ± 3.1	15 (55.6)	3.1 ± 3.5	9 (39.1)	1.5 ± 2.4	14 (50.0)	2.4 ± 2.9	0.35	0.31
Deep pain with intercourse	60 (56.1)	3.1 ± 3.4	16 (59.3)	3.1 ± 3.4	7 (30.4)	1.8 ± 3.0	15 (53.6)	2.9 ± 3.4	0.14	0.27
Burning vaginal pain after intercourse	36 (33.6)	1.4 ± 2.6	11 (40.7)	1.6 ± 2.2	5 (21.7)	0.6 ± 1.3	10 (35.7)	1.1 ± 2.0	0.55	0.43
Pelvic pain lasting hours or days after intercourse	39 (36.5)	1.6 ± 2.7	9 (33.3)	2.3 ± 3.6	4 (17.4)	0.6 ± 1.6	6 (21.4)	0.9 ± 2.1	0.19	0.16
Constant burning vaginal pain (regardless of intercourse)	13 (12.2)	0.4 ± 1.5	6 (22.2)	0.9 ± 2.1	0 (0)	0 ± 0	6 (21.4)	0.9 ± 1.9	0.07	0.07
Dysmenorrhea
Pain just before menstrual period	77 (72)	4.0 ± 3.3	24 (88.9)	5.0 ± 3.1	17 (73.9)	4.0 ± 2.8	22 (78.6)	4.1 ± 3.2	0.32	0.47
Level of cramps with period	95 (88.8)	6.3 ± 3.3	24 (88.9)	7.1 ± 3.4	23 (100)	6.9 ± 2.7	26 (92.9)	6.4 ± 3.0	0.37	0.50
Pain after period is over	38 (35.5)	1.6 ± 2.7	12 (44.4)	2.2 ± 3.2	8 (34.8)	1.8 ± 3.2	11 (39.3)	2.4 ± 3.5	0.84	0.74
Ovulatory related pain
Pain at ovulation (mid-cycle)	70 (65.4)	3.2 ± 3.1	21 (77.8)	3.1 ± 2.6	17 (73.9)	3.7 ± 3.1	17 (60.7)	2.5 ± 2.9	0.47	0.46
Dysuria
Pain with urination	25 (23.4)	1.0 ± 2.3	8 (29.6)	1.1 ± 1.9	4 (17.4)	0.7 ± 1.8	4 (14.3)	0.8 ± 2.3	0.52	0.59
	Stage I (n = 107)		Stage II (n = 27)		Stage III (n = 23)		Stage IV (n = 28)		P
									P (n [%])	P (mean ± SD)
Dyschezia
Pain with bowel elimination	42 (39.3)	2.0 ± 3.0	13 (48.2)	2.1 ± 3.1	12 (52.2)	2.1 ± 2.4	13 (46.4)	2.6 ± 3.2	0.61	0.80
Other pain
Pain in groin when lifting	28 (26.2)	1.3 ± 2.4	9 (33.3)	1.3 ± 2	4 (17.4)	0.8 ± 1.8	6 (21.4)	0.9 ± 2.2	0.58	0.61
Pain when bladder is full	60 (56.1)	2.3 ± 2.8	11 (40.7)	2.3 ± 3.3	12 (52.2)	2.1 ± 2.7	14 (50)	1.9 ± 2.6	0.55	0.84
Abdominal pain	52 (48.6)	2.7 ± 3.4	14 (51.9)	2.6 ± 3.1	13 (56.5)	3.0 ± 3.3	14 (50)	2.3 ± 3.2	0.92	0.92
Low back pain	84 (78.5)	4.2 ± 3.2	18 (66.7)	3.0 ± 3.1	14 (60.9)	2.9 ± 3.2	18 (64.3)	3.5 ± 3.6	0.18	0.12
Muscle/joint pain	55 (55.0)	2.8 ± 3.2	14 (51.9)	2.4 ± 2.9	9 (39.1)	2.6 ± 3.5	15 (55.6)	2.4 ± 2.8	0.57	0.89
Migraine headache	59 (57.8)	3.8 ± 3.9	14 (51.9)	3.0 ± 3.6	10 (43.5)	3.1 ± 4.1	12 (44.4)	2.4 ± 3.0	0.46	0.31
Pain medicationsc (n [%])
Over-the-counter pain medications	81 (83.5)		23 (88.5)		23 (100)		24 (96.0)		0.08
Narcotic prescription medications	30 (30.9)		8 (30.8)		9 (39.1)		4 (16.0)		0.35
Non-narcotic prescription medications	18 (18.6)		5 (19.2)		3 (13.0)		4 (16.0)		0.92
None	8 (8.3)		0 (0)		0 (0)		0 (0)		0.09

^aIncludes 185 women in the ENDO operative cohort with endometriosis diagnosis and automatically calculated rASRM weighted point score for staging (all 190 women had staging based on operating surgeons' empiric assessment). Missing 0 observations for chronic pain, 0 for cyclic pain, 0 for pain type and 14 for pain medications. Statistical significance for differences was assessed via Wilcoxon–Mann–Whitney test for continuous variables and chi-square or Fisher's exact tests for categorical variables. Values sharing a common superscript are significantly different P < 0.05 via multiple comparison tests (Tukey procedure for frequencies and Dwass, Steel, Critchlow-Fligner procedure [based on pairwise two-sample rankings] for means).

^b11-point visual analog scale with 0 being no pain and 10 being the most severe pain imaginable, women reported any pain in the last 6 months (no minimum duration required). Mean ± SD for pain on original VAS scale (0 to 10).

^cPain medications taken on at least a monthly basis for any indication in the past 12 months.