Fig 6. Schematic model of NBCe1-B and NBCn1 regulation by Src kinase.

NBCe1-B and NBCn1 mediate intracellular pH in an HSG cell line and human submandibular glands, especially on the apical side of duct cells. NBCe1-B is phosphorylated by Src kinase and translocates to the plasma membrane, whereas the NBCn1 is not regulated by Src kinase. The effect of Src kinase is inhibited by PP2. Arrows indicate activation and bars indicate inhibition.