Table 1.
Diversity of HLA alleles’ expression for MS patients in different geographical areas and ethnic groups on published data.
| Diversity of HLA Alleles Expression in Multiple Sclerosis | |
|---|---|
| Northern Europeans (Australia, Scandinavia, New England) | DR15 (DRB1*1501-DRB5*0101) |
| Africans | A low frequency of DRB1*1501 |
| African American | Great variability of the locus DRB1 DRB1*1501, DRB1*1503 and DRB1*0301 |
| Martinique | DRB1*07; and the most common subtype of DRB1*15 was *1503, not *1501 |
| United States | HLA-DRB1 and the DR2 haplotype (DRB1*1501-DQB1*0602) |
| Mexicans | Two Class II novel associations DRB1*0403, DRB1*0802 |
| Asiatic Indians and Afro-Caribbean | DRB1*1501, DQA1*0102, DQB1*0601 Low association with MS |
| Afro-Brazilian | DQB1*0602 genetic susceptibility |
| Malaga, Spain | DRB1*1501, DQA1*0102 and DQB1*0602 |