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ISG15 is increased in the serum of Apc Min/+ Klf9 +/− and Apc Min/+ Klf9 −/− mice and in the colon mucosa of Apc Min/+/Klf9 +/− mice at 8 weeks of age. ISG15 levels in serum (A) and colon mucosa lysate (B) in Apc Min/+/Klf9 +/+ (+/+), Apc Min/+/Klf9 +/− (+/−), and Apc Min/+/Klf9 −/− (−/−) mice. Bar graphs represent mean ± SEM. *P < 0.05 relative to (+/+) group.
