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. 2015 Jul 25;36(9):946–955. doi: 10.1093/carcin/bgv104

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Figure 6. — ISG15 reduces apoptosis in HT29 cells. (A–D) Representative flow cytometry analysis of Annexin V-FITC staining in HT29 cells after 48-h treatment with either control medium (A), 50 μM 5-fluorouracil (B), 100ng/ml ISG15 (C) or ISG15 + 5-fluorouracil (D). Left side of each panel: total population, forward and side scatter; right side: gated cells, X: Annexin V-FITC, Y: Propidium Iodide. (E) Summary of percentages of apoptotic cells from three independent experiments. (F) mRNA expression of apoptosis-related genes in colon mucosa of Apc ^Min/+/Klf9 ^+/+ , Apc ^Min/+/Klf9 ^+/− and Apc ^Min/+/Klf9 ^−/− mice (n = 7–9/genotype). Bar graphs represent mean ± SEM. *P < 0.05 relative to control. **P < 0.01 relative to control.