Table 3.
Dosimetric changes in different target volumes
| Plan-0 | Plan-1 | Plan-2 | Plan-3 | Plan-4 | Plan-5 | |
|---|---|---|---|---|---|---|
| PTVnx | ||||||
| Dmean (Gy) | 71.17 ± 1.49 | 71.31 ± 1.44 | 71.41 ± 1.43 | 71.50 ± 1.40 | 71.60 ± 1.42 | 71.61 ± 1.44 |
| P value | 0.073 | 0.004 | 0.001 | <0.001 | 0.001 | |
| D95 (Gy) | 67.40 ± 2.48 | 67.54 ± 2.32 | 67.64 ± 2.25 | 67.86 ± 2.26 | 68.23 ± 2.04 | 68.18 ± 2.17 |
| P value | 0.404 | 0.256 | 0.040 | 0.004 | 0.015 | |
| V110 (%) | 0.29 ± 0.65 | 0.30 ± 0.64 | 0.34 ± 0.75 | 0.29 ± 0.70 | 0.31 ± 0.86 | 0.32 ± 0.88 |
| P value | 0.447 | 0.102 | 0.990 | 0.887 | 0.852 | |
| V95 (%) | 95.97 ± 5.06 | 96.29 ± 4.76 | 96.68 ± 4.4 | 97.21 ± 3.77 | 97.72 ± 3.59 | 97.48 ± 4.34 |
| P value | 0.158 | 0.032 | 0.013 | 0.005 | 0.027 | |
| HI | 1.09 ± 0.03 | 1.09 ± 0.03 | 1.09 ± 0.03 | 1.09 ± 0.03 | 1.09 ± 0.03 | 1.09 ± 0.03 |
| P value | 0.244 | 0.244 | 0.116 | 0.258 | 0.678 | |
| CI | 0.76 ± 0.24 | 0.77 ± 0.24 | 0.78 ± 0.23 | 0.80 ± 0.22 | 0.81 ± 0.22 | 0.82 ± 0.21 |
| P value | 0.141 | 0.044 | 0.005 | 0.004 | 0.004 | |
| PTVnd | ||||||
| Dmean (Gy) | 71.60 ± .08 | 71.51 ± 1.08 | 71.56 ± 1.12 | 71.68 ± 1.08 | 71.73 ± 1.25 | 71.81 ± 1.22 |
| P value | 0.134 | 0.634 | 0.334 | 0.312 | 0.090 | |
| D95 (Gy) | 66.43 ± 3.16 | 66.88 ± 3.31 | 66.89 ± 3.27 | 67.03 ± 3.27 | 67.27 ± 3.98 | 67.60 ± 3.57 |
| P value | 0.093 | 0.116 | 0.025 | 0.061 | 0.011 | |
| V110 (%) | 0.74 ± 1.43 | 0.70 ± 1.29 | 0.71 ± 1.37 | 0.74 ± 1.45 | 0.8 ± 1.66 | 0.76 ± 1.65 |
| P value | 0.528 | 0.386 | 0.984 | 0.984 | 0.902 | |
| V95 (%) | 95.09 ± 4.56 | 96.02 ± 4.21 | 96.02 ± 4.43 | 96.09 ± 4.47 | 96.66 ± 5.44 | 96.75 ± 5.85 |
| P value | 0.066 | 0.034 | 0.050 | 0.010 | 0.033 | |
| HI | 1.10 ± 0.04 | 1.10 ± 0.04 | 1.10 ± 0.04 | 1.10 ± 0.04 | 1.10 ± 0.03 | 1.10 ± 0.03 |
| P value | 0.282 | 0.159 | 0.056 | 0.186 | 0.150 | |
| CI | 0.80 ± 0.20 | 0.79 ± 0.18 | 0.80 ± 0.18 | 0.81 ± 0.18 | 0.82 ± 0.19 | 0.83 ± 0.18 |
| P value | 0.355 | 0.951 | 0.244 | 0.063 | 0.102 | |
| PTV1 | ||||||
| Dmean (Gy) | 68.06 ± 2.22 | 68.38 ± 2.03 | 68.52 ± 2.04 | 68.62 ± 1.96 | 68.69 ± 2.05 | 68.74 ± 2.06 |
| P value | 0.014 | 0.001 | 0.003 | 0.001 | 0.001 | |
| D95 (Gy) | 60.00 ± 4.12 | 60.63 ± 3.91 | 61.04 ± 4.11 | 61.08 ± 4.33 | 61.24 ± 4.41 | 61.20 ± 4.43 |
| P value | 0.146 | 0.020 | 0.004 | 0.017 | 0.009 | |
| V95 (%) | 95.58 ± 4.23 | 96.80 ± 2.97 | 96.90 ± 3.17 | 96.69 ± 3.73 | 96.79 ± 3.59 | 96.93 ± 3.46 |
| P value | 0.093 | 0.071 | 0.051 | 0.077 | 0.019 | |
| HI | 1.25 ± 0.03 | 1.25 ± 0.03 | 1.25 ± 0.03 | 1.25 ± 0.03 | 1.25 ± 0.03 | 1.25 ± 0.03 |
| P value | 0.478 | 0.706 | 0.258 | 0.053 | 0.086 | |
| CI | 0.90 ± 0.07 | 0.92 ± 0.05 | 0.93 ± 0.06 | 0.93 ± 0.05 | 0.93 ± 0.06 | 0.93 ± 0.06 |
| P value | 0.040 | 0.038 | 0.006 | 0.046 | 0.008 | |
| PTV2 | ||||||
| Dmean (Gy) | 60.21 ± 6.65 | 59.98 ± 6.73 | 60.07 ± 6.90 | 60.10 ± 6.80 | 60.08 ± 6.94 | 60.20 ± 6.64 |
| P value | 0.071 | 0.345 | 0.412 | 0.379 | 0.940 | |
| D95 (Gy) | 47.47 ± 6.42 | 46.73 ± 6.12 | 46.94 ± 6.18 | 46.89 ± 6.21 | 46.75 ± 16.1 | 46.61 ± 6.06 |
| P value | 0.008 | 0.069 | 0.038 | 0.020 | 0.023 | |
| V95 (%) | 92.48 ± 0.97 | 91.39 ± 1.10 | 91.74 ± 1.12 | 91.84 ± 0.92 | 91.56 ± 1.25 | 91.52 ± 0.52 |
| P value | 0.015 | 0.071 | 0.088 | 0.028 | 0.057 | |
| HI | 1.42 ± 0.05 | 1.42 ± 0.05 | 1.42 ± 0.05 | 1.42 ± 0.05 | 1.42 ± 0.05 | 1.42 ± 0.05 |
| P value | 0.334 | 0.229 | 0.167 | 0.173 | 0.130 | |
| CI | 0.87 ± 0.13 | 0.86 ± 0.13 | 0.86 ± 0.13 | 0.86 ± 0.13 | 0.86 ± 0.13 | 0.86 ± 0.13 |
| P value | 0.032 | 0.184 | 0.271 | 0.082 | 0.173 |
Difference was calculated by comparing Plan-0 and each hybrid plan
Dmean mean dose, D95 dose to 95 % of the volume, V110 percentage of the volume receiving more than 110 % of the prescription dose, V95 percentage of the volume receiving 95 % of the prescription dose, HI homogeneity index, CI conformity index