FIG 7.
TREG cells protect against hypertension-driven fibrosis in an immunosuppression-independent manner. (A to E) Renal fibrosis (A and D), abundance of Lcn2 transcripts in kidneys (B), and AUC for mean arterial pressure levels (C and E) in the indicated mouse strains under the indicated treatment conditions. Asterisks indicate significant differences (*, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001) from the control or between the indicated experimental groups (n = 4). (F and G) Representative dot plots (F) and quantification (G) of kidney-resident neutrophils in the indicated mouse strains under the indicated treatment conditions. Asterisks indicate significant differences (*, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001) from the control or between the indicated experimental groups (n = 4). (H and I) Percentages of kidney-resident and circulating neutrophils in Foxn1nu mice under the indicated experimental conditions. Asterisks indicate significant differences (*, P ≤ 0.05) from the control (n = 4).