FIG 1.

Major components of c-di-AMP signaling in B. subtilis studied in this work. (A) Cyclic di-AMP signaling in B. subtilis. Transmembrane regions are depicted as barrels, with one barrel per transmembrane domain. The three diadenylate cyclases, DisA, CdaA, and CdaS, are shown in yellow. CdaR and GlmM are shown in green and red, respectively. The phosphodiesterases GdpP and PgpH are shown in black. Please note that the illustration is not shown to scale. (B) Genetic organization of the highly conserved cda-glm operon in firmicutes. The operon is expressed under the control of a constitutive promoter; in addition, glmS is controlled by the glucosamine 6-phosphate-responsive glmS ribozyme.