Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Second-site suppressor alterations in the AcrB-F610A protein
| Codon change (no. of isolates) | AcrB substitution | Affected AcrB domain/region |
|---|---|---|
| TAC → TCC (1) | Y49S | PN1, near exit gate |
| GTG → GCG (1) | V127A | PN1 |
| GTG → GGG (1) | V127G | PN1 |
| GAT → GAA (1) | D153E | PN2 |
| GGT → TGT (5) | G288C | PN2, distal drug binding pocket |
| TTC → TGC (1) | F453C | TM5 |
| TTG → TGG (1) | L486W | TM6 |
