Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Effects of G288D mutation in the wild-type and F610A backgrounds on MICs of inhibitors
| AcrB protein or substitution(s)a | MIC (μg/ml)b |
|||||
|---|---|---|---|---|---|---|
| Ery | Nov | Min | Nal | Cip | SDS | |
| AcrB-WT | 128 | 128 | 1 | 4 | 0.032 | 800 |
| F610A | 4 | 16 | 0.25 | 1–2 | 0.008 | 400 |
| G288D | 64 | 64 | 0.5 | 4 | 0.032 | 400 |
| F610A, G288D | 64 | 64 | 1 | 4 | 0.032 | 800 |
The G288D substitution involved changing the GGT codon to GAT.
Ery, erythromycin; Nov, novobiocin; Min, minocycline; Nal, nalidixic acid; Cip, ciprofloxacin; SDS, sodium dodecyl sulfate.
