Table 1.
Clinical characteristics of patients with leukemia
| Patient | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 |
|---|---|---|---|---|---|---|---|---|---|
| Age (years) | 35 | 5 | 24 | 10 | 6 | 58 | 24 | 16 | 8 |
| Sex | F | F | M | F | F | F | M | M | M |
| Chief complaints | |||||||||
| Fever | + | + | − | + | + | + | + | + | + |
| Bone pain | + | + | + | + | + | + | + | − | + |
| Laboratory data | |||||||||
| WBC (/µL) | 2700 | 6900 | 4400 | 18,100 | 11,900 | 1100 | 9100 | 175,100 | 11,100 |
| Leukemic cells (%) | 0 | 0 | 0 | 64 | 11.5 | 3 | 21.5 | 4.5 | 12 |
| Hb (g/dL) | 10.3 | 11.0 | 12.4 | 12.1 | 11.8 | 8.6 | 14.3 | 10.5 | 12.5 |
| PLT (×103/μL) | 340 | 300 | 48 | 22 | 115 | 58 | 184 | 59 | 63 |
| LDH (IU/L) | 190 | 183 | 262 | 955 | 367 | 300 | 489 | 972 | 11,021 |
| CRP (mg/dL) | 5.1 | 4.2 | 7.3 | 2.4 | 11.9 | 8.3 | 3.2 | 0.6 | 0.8 |
| FDG-PET | |||||||||
| Abnormal BM uptake | + | + | + | + | + | + | + | + | + |
| SUVmax of BM | 6.8 | 4.5 | 5.6 | 6.0 | 6.1 | 6.1 | 14.0 | 4.8 | 5.9 |
| SUVmax of liver | 2.4 | 1.4 | 4.2 | 2.4 | 2.5 | 2.6 | 2.7 | 2.7 | 1.3 |
| Lymph node swelling | − | − | − | − | − | − | − | − | − |
| Splenomegaly | − | − | − | + | + | − | + | + | + |
| Increased uptake in spleen | − | − | − | + | + | + | + | − | + |
| Extramedullary lesion | − | − | − | − | − | − | − | − | − |
| Diagnosis | B-ALL | B-ALL | B-ALL | B-ALL | B-ALL | AML | B-ALL | CML | mature B |
| Time to diagnosis (months) | 20 | 4 | 6 | 0 | 1 | 0 | 0 | 0 | 1 |
| Treatment | CBT | CTX | CBT | CTX | CTX | BMT | CBT | CTX | CTX |
| Outcome | CR | CR | PR | PR | PR | PR | PR | Dead | – |
| Follow-up (months) | 33 | 22 | 21 | 19 | 18 | 17 | 14 | 1 | 3 |
WBC white blood cell count, Hb hemoglobin, PLT platelet count, LDH lactate dehydrogenase, CRP C-reactive protein, BM bone marrow, B-ALL B-cell acute lymphoblastic leukemia, AML acute myeloid leukemia, CML chronic myeloid leukemia, CBT cord blood stem cell transplantation, CTX chemotherapy, BMT bone marrow transplantation, CR complete remission, PR partial remission