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. Author manuscript; available in PMC: 2016 May 18.
Published in final edited form as: Mol Psychiatry. 2015 Mar 17;21(1):108–117. doi: 10.1038/mp.2015.23

Figure 1.

Figure 1

Association of AD with SNPs in chromosome 17q21.31 in the combined stage 1 and stage 2 samples. (A) Regional Manhattan plot in the APOE ε4+ (upper panel) and the APOE ε4− (lower panel) subgroups. SNPs with the lowest P-value are indicated with a purple diamond. Computed estimates of linkage disequilibrium (r2) of SNPs in this region with the most significant SNP are shown as red circles for r2 ≥ 0.8, orange circles for 0.6 ≤ r2 < 0.8, green circles for 0.4 ≤ r2 < 0.6, light blue circles for 0.2 ≤ r2 < 0.4, and blue circles for r2 < 0.2. Unannotated SNPs are shown as grey circles. (B) Forest plot of association results for rs2732703 in the Stage 1, Stage 2 and total samples among APOE ε4− subjects.