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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Pharmacol Biochem Behav. 2015 Mar 17;139(0 0):103–111. doi: 10.1016/j.pbb.2015.03.006

Table 1. Cognitive Effects of Psychoactive Drugs in Zebrafish.

Authors Compound Effect Assay
Braida et al., 2014b Nicotine Improved performance T-maze
Braida et al., 2014b Nicotine Increased discrimination score Object recognition test
Eddins et al., 2009; Levin & Chen, 2004; Levin et al., 2006 Nicotine Increased accuracy Spatial discrimination test
Kedikian et al., 2013 Nicotine Enhanced place preference Conditioned place preference (for drug)
Braida et al., 2014b Cytisine (and cytisine-derived partial agonists) Improved performance T-maze
Darland & Dowling 2001; Darland et al., 2012 Cocaine Enhanced place preference Conditioned place preference (for drug)
Webb et al., 2009; Ninkovic & Bally-Cuif, 2006 Amphetamine Enhanced place preference Conditioned place preference (for drug)
Chacon & Luchiari, 2014; Mathur et al., 2011 Ethanol Enhanced place preference Conditioned place preference (for drug)
Chacon & Luchiari, 2014 Ethanol Memory impairment Associative learning
Pittman & Lott, 2014 Ethanol Impaired performance Vertical column plus-maze
Lau et al., 2006 Morphine Enhanced place preference Conditioned Place Preference (for drug)
Kim et al., 2010; Richetti et al., 2011 Scopolamine Memory impairment Passive avoidance
Cognato et al., 2012 Scopolamine Reduced exploration (novel arm) Y-maze
Sison & Gerlai, 2011 MK-801 Learning impairment Associative learning
Swain et al., 2004 MK-801 Decreased place preference Conditioned Place Preference (for food)
Cognato et al., 2012 MK-801 Memory impairment Y-maze
Blank et al., 2009; Ng et al., 2012; Seibt et al., 2011 MK-801 Learning/memory impairment Avoidance learning (various)
Cofiel & Mattiolo, 2009 L-histidine Facilitated learning Associative learning
Pittman & Lott, 2014 Fluoxetine Impaired performance Plus maze
Grossman et al., 2011 Piracetam Improved performance Plus maze
Ruhl et al., 2014 THC Memory impairment Spatial memory test
Grossman et al., 2010 LSD Improved performance T-maze
Braida et al., 2007 Salvinorin A Enhanced place preference Conditioned place preference (for drug)