Table 2. Factors predicting SA colonization of the nasopharynx at any time during monthly evaluation (n =1765 cultures from 367 infants).
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
|
| ||||
| Factor | Coefficient (95% CI) | P value | Coefficient (95% CI) | P value |
|
| ||||
| Age | -0.011 (-0.014, -0.0079) | <0.001 | -0.0086 (-0.012, -0.0050) | <0.001 |
|
| ||||
| Gender (ref. female) | -0.29 (-0.81, 0.23) | 0.27 | -0.34 (-0.90, 0.22) | 0.24 |
|
| ||||
| Race/ethnicity | ||||
| White* | 0.013 (-0.57, 0.59) | 0.96 | Comparator | |
| Hispanic | 0.40 (-0.12, 0.93) | 0.13 | 0.16 (-0.52, 0.84) | 0.64 |
| Black | -0.62 (-1.28, 0.0049) | 0.056 | -0.78 (-1.63, 0.081) | 0.076 |
| Asian | 0.26 (-2.04, 2.44) | 0.81 | 0.24 (-2.20, 2.68) | 0.85 |
|
| ||||
| Breastfeeding | -0.35 (-0.86, 0.16) | 0.18 | -0.51 (-1.07, 0.054) | 0.076 |
|
| ||||
| Cigarette smoke exposure | -0.27 (-0.88, 0.31) | 0.37 | -0.11 (-0.76, 0.54) | 0.74 |
|
| ||||
| Daycare attendance | -0.74 (-1.42, -0.094) | 0.028 | 0.10 (-0.61, 0.81) | 0.78 |
|
| ||||
| NTHI Colonization | -1.12 (-1.76, -0.53) | <0.001 | -0.41 (-1.09, 0.27) | 0.23 |
|
| ||||
| MC colonization | -1.09 (-1.52, -0.68) | <0.001 | -0.52 (-1.00, -0.034) | 0.036 |
|
| ||||
| SP colonization | -0.84 (-1.38, -0.33) | 0.002 | 0.011 (-0.59, 0.61) | 0.97 |
*
Non-Hispanic white
Above statistical analysis used logistic mixed model. This model took into account a child with multiple positive SA samples All of the factors were present prior to the positivity of SA colonization. NS = not significant; URI = upper respiratory infection; SA = S. aureus, SP = S. pneumoniae, NTHI = non-typeable H. influenzae, MC = M. catarrhalis; CI = confidence interval.