Table 2.
Association of infant growth (n=58) and whole body bone mineral content (n=49) with meconium tenofovir (TFV) concentration
| Infant Growth Outcomes at Birtha | Median (Range) for Infant Growth Outcomes | Univariate Coefficient (95% CI) for Association with Meconium TFVb | P-value | Multivariate Coefficient (95% CI) for Association with Meconium TFVbc | P-value |
|---|---|---|---|---|---|
| Birth weight (kg) | 3.1 (2.0 – 4.1) |
0.0000 (−0.0022, 0.0021) |
0.98 | 0.0001 (−0.0024, 0.0025) |
0.97 |
| Birth length (cm) | 49.5 (43.1 – 53.5) |
0.0066 (−0.0045, 0.0178) |
0.24 | 0.0035 (−0.0089, 0.0157) |
0.57 |
| WHO weight-for-age z-scored | −0.57 (−3.26 – 1.20) |
0.0000 (−0.0046, 0.0046) |
0.99 | 0.0008 (−0.0045, 0.0061) |
0.77 |
| WHO length/height-for-age z-scored | −0.51 (−4.04 – 2.23) |
0.0032 (−0.0030, 0.0094) |
0.31 | 0.0022 (−0.0045, 0.0088) |
0.52 |
| WHO weight-for-length/height z-scoree | −0.30 (−4.11 – 2.39) |
−0.0049 (−0.0107, 0.0010) |
0.10 | −0.0015 (−0.0074, 0.0044) |
0.61 |
|
| |||||
| Whole Body Infant DXA Outcomesa | Median (range) for Infant DXA Outcome | Univariate Coefficient (95% CI) for Association with Meconium TFVb | P-value | Multivariate Coefficient (95% CI) for Association with Meconium TFVbf | P-value |
|
| |||||
| Whole body bone mineral content (BMC, g) | 60 (38 – 87) |
0.028 (−0.023, 0.080) |
0.28 | 0.025 (−0.029, 0.078) |
0.35 |
Most (71%) growth outcomes were obtained within 72 hours of birth and all were collected within 30 days. Bone outcomes were obtained prior to 4 weeks of age.
Coefficients represent difference in growth outcomes or BMC for each one unit increase in square-root transformed TFV meconium concentrations
Multivariable models adjusted for site, maternal age at delivery, alcohol and tobacco use during pregnancy, concomitant maternal PI use, infant gestational age, and infant race/ethnicity.
Unknown data for 1 participant
Unknown data for 3 participants
The multivariable model adjusted for site, maternal age at delivery, alcohol and tobacco use during pregnancy, concomitant maternal PI use, infant gestational age, infant race/ethnicity, infant birth length, and infant age at DXA.
CI indicates confidence interval