Table 1.
Subject demographics
| Total progressive apraxia of speech cohort (n=24) | PPAOS subset (n=15) | Controls (n=20) | |
|---|---|---|---|
| Age at baseline MRI, years | 72 (65–76) | 74 (67–76) | 72 (67–76) |
| Gender, % female | 15 (62%) | 8 (53%) | 11 (55%) |
| Scan interval, years | 2 (1.5–2.4) | 2 (1.7–2.6) | 2 (1.7–2.6) |
| Disease duration, years | 4 (2.6–4.9) | 4 (2.9–5.4) | NA |
| ASRS at baseline (/64, 0 normal) | 16 (12–23) | 16 (12–20) | NA |
| ASRS at follow-up (/64, 0 normal)a | 26 (20–31) | 25 (20–31) | NA |
| MSD scale at baseline (/10, 10 normal) | 7 (6–8) | 7 (7–8) | NA |
| MSD scale at follow-up (/10, 10 normal) | 6 (4–6) | 6 (4–6) | NA |
| WAB-AQ at baseline (/100, 100 normal) | 95 (85–98) | 97 (95–100) | NA |
| WAB-AQ at follow-up (/100, 100 normal)b | 87 (82–96) | 96 (87–97) | NA |
Data shown as median (inter-quartile range); ASRS = Apraxia of Speech Rating Scale; MSD = Motor Speech Disorder scale; WAB – AQ = Western Aphasia Battery Aphasia Quotient; no significant differences were observed between progressive apraxia of speech and controls or between PPAOS and controls.
a
Two patients (one diagnosed with PPAOS) were unable to complete the ASRS at follow-up.
b
Four patients (two diagnosed with PPAOS) were unable to complete the WAB-AQ at follow-up