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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Paediatr Drugs. 2015 Oct;17(5):401–410. doi: 10.1007/s40272-015-0139-z

Appendix Table 2.

Sensitivity Analysis for Measures of Therapeutic Adjustment after Treatment Initiation with First- and Second-Generation Antiepileptics

First Treatment
Medication		 1. Proportion
monotherapy
(95% CI)		 2. Proportion
polytherapy
(95% CI)		 3. Number of
antiepileptic
drugs,
mean (95% CI)		 4. Number of
therapeutic
adjustments,
mean (95% CI)
All antiepileptics 69.8 (68.8, 71.1) 9.2 (8.4, 10.0) 1.4 (1.4, 1.4) 1.8 (1.8, 1.9)
  First-generation drugs 68.6 (66.8, 70.2) 9.2 (8.2, 10.3) 1.4 (1.4, 1.4) 1.8 (1.7, 1.9)
  Second-generation drugs 71.5 (69.6, 73.4) 9.1 (7.9, 10.3) 1.4 (1.4, 1.4) 1.8 (1.8, 1.9)