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. Author manuscript; available in PMC: 2016 Sep 15.
Published in final edited form as: Cancer Res. 2015 Jul 24;75(18):3970–3979. doi: 10.1158/0008-5472.CAN-15-0234

Figure 3. Maspin expression induces prostate cancer cell dedifferentiation in 3D collagen I.

Figure 3

(A) Phase contrast representative fields of isogenic pairs of prostate cancer cells expressing low (left hand panel) and high maspin (right hand panel), embedded in 3D collagen I at days 12-17 (Scale = 50 μm). (B) Confocal fluorescence imaging of the nuclei of M7 cells in 3D collagen I (top, scale = 50 μm) and Neo cells in suspension (bottom, scale = 100 μm) stained with Hoechst dye (blue).