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. Author manuscript; available in PMC: 2016 Sep 15.
Published in final edited form as: Cancer Res. 2015 Jul 24;75(18):3713–3719. doi: 10.1158/0008-5472.CAN-15-0562

Figure 3.

Figure 3

Wild-type allele of BRAF inhibits metastasis and tumor growth. A, wild-type BRAF was reintroducted into MDA231-BrM2-1 cells and compared with cells expressing an empty vector in vivo. One thousand cells were injected into the left ventricle of mice. Tumor burden was quantitated by bioluminescence imaging at 9 weeks. n = 10, empty vector; n = 7 wild-type BRAF B, one hundred MDA231-BrM2-1 cells expressing either empty vector or wild-type BRAF were suspended in matrigel and innoculated subcutaneously into the flanks of immunodeficient mice (n = 20 per condition). Tumor burden was quantitated by bioluminescence imaging at 7 weeks. P values shown was calculated by a two-tailed Wilcoxon rank sum test. * - p<0.05, ** - p<0.01.