Skip to main content
. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Cancer Chemother Pharmacol. 2015 Sep 1;76(4):803–811. doi: 10.1007/s00280-015-2857-x

Figure 1.

Figure 1

Plasma concentration versus time profiles following 500 mg/kg THU and 10 mg/kg FdCyd PO to female (A) and male (B) or 30 mg/kg THU and 8 mg/kg FdCyd IV to female (C) cynomolgus monkeys. For the PO administration, THU was administered as a bolus 1 h prior to bolus FdCyd. For IV administration, the initial 20% of the daily dose of THU was administered as an IV bolus injection immediately prior to the initiation of the FdCyd dose. The remaining 80% of the daily dose of THU was co-administered with the FdCyd dose as a 3 h infusion. Closed and open symbols represent individual monkeys, respectively ▲or △ represents FdCyd; ● or ○ represents FdUrd; ▼ or ▽ represents FU; ♦ or ♢ represents FC; and ■ or □ represents THU.