Table 3.
Non-compartmental pharmacokinetic parameters of FdCyd and metabolites, and THU after administration of FdCyd and THU to seven humans IV-IV (100 mg/m2–350 mg/m2), PO-PO (100 mg/m2–1750 mg/m2), and PO-IV (100 mg/m2–350 mg/m2) route, respectively.
| FdCyd THU |
IV 100 mg/m2 IV 350 mg/m2 |
PO 100 mg/m2 PO 1750 mg/m2 |
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| Dose (mg/m2) |
Analyte | Cmax (ng/mL) |
AUCinf (µg•min/mL) |
Cmax (ng/mL) |
AUCinf (µg•min/mL) |
Fa (%) |
| N=7 | FdCyd | 4107 (1368) | 912 (341) | 623 (444) | 95.9 (62.0) | 10.1 (4.8) |
| FdUrd | 24.1 (8.0) | 7.03 (1.29) | 28.4 (11.5) | 4.04 (1.31) | ||
| FU | 9.72 (6.75) | 6.03 (7.70) | 14.1 (4.1) | 4.47 (5.08) | ||
| THU | 16452 (2154) | 7969 (1925) | 1428 (811) | 1606 (748) | 4.1 (1.5) | |
a
, calculated by F = (AUCpo/AUCiv)*(Doseiv/Dosepo).