Table 1. Comparison between tractography results and histological reference data in healthy volunteers.

		OR-TCT (iFOD2)		OR-TCT (iFOD2 + AEC)		reference mask a
		HARDI A b	HARDI B c	HARDI A b	HARDI B c	Histological
Tract volume (cm 3), mean (±SD)	lh	44.87 (±7.69)	52.38 (±14.46)	12.25 (±2.73)	16.81 (±4.89)	18.4 (±2.1)
	rh	41.69 (±8.00)	43.37 (±11.03)	12.01 (±2.03)	14.99 (±3.52)	18.4 (±1.3)
Sensitivity	lh	0.99	0.99	0.71	0.81	-
	rh	0.99	1.00	0.65	0.70	-
Precision	lh	0.18	0.14	0.83	0.71	-
	rh	0.20	0.17	0.83	0.79	-
Specificity	lh	0.92	0.90	1.00	0.99	-
	rh	0.93	0.92	1.00	1.00	-
F-measure	lh	0.30	0.25	0.77	0.76	-
	rh	0.33	0.29	0.73	0.74	-

^aVolumes in the histological reference mask were obtained from Clatworthy et al., 2010.

^bHARDI A: 1.5 mm isotropic voxel size; b-value, 1500 s/mm ²

^cHARDI B: 2.5 mm isotropic voxel size; b-value, 1000 s/mm ²

Abbreviations:

AEC: automatic post-processing based on anatomical exclusion criteria.

iFOD: high order integration over fiber orientation distributions.

lh: left hemisphere.

OR-TCT: optic radiation tractography-constructed template.

rh: right hemisphere.