(a).
Parameter | Protocol | HC | MCS patients | UWS patients | ||||||
---|---|---|---|---|---|---|---|---|---|---|
T pre | T post | T +30 | T pre | T post | T +30 | T pre | T post | T +30 | ||
RMT (%) | rES_alone | 58 | 52 | 52 | 58 | 56 | 58 | 58 | 62 | 67 |
52 | 57 | 58 | 60 | 57 | 55 | 68 | 59 | 57 | ||
53 | 57 | 57 | 59 | 54 | 58 | 57 | 60 | 53 | ||
55 | 55 | 54 | 56 | 60 | 55 | 60 | 62 | 57 | ||
58 | 58 | 54 | 59 | 55 | 56 | 66 | 59 | 56 | ||
52 | 56 | 55 | 56 | 58 | 59 | 55 | 66 | 67 | ||
53 | 55 | 53 | 58 | 60 | 57 | 57 | 55 | 65 | ||
56 | 52 | 53 | 57 | 58 | 59 | 66 | 62 | 60 | ||
56 | 55 | 52 | 56 | 60 | 56 | 53 | 60 | 61 | ||
57 | 55 | 53 | 57 | 59 | 58 | 64 | 63 | 54 | ||
55 ± .7 | 55 ± .6 | 54 ± .6 | 58 ± .5 | 58 ± .7 | 57 ± .5 | 60 ± 1.7 | 61 ± .9 | 60 ± 1.6 | ||
rTMS_alone | 54 | 54 | 56 | 57 | 54 | 60 | 68 | 53 | 65 | |
53 | 56 | 53 | 57 | 55 | 58 | 63 | 63 | 65 | ||
58 | 52 | 57 | 58 | 59 | 57 | 67 | 55 | 53 | ||
55 | 58 | 53 | 59 | 59 | 55 | 66 | 67 | 60 | ||
53 | 55 | 58 | 54 | 55 | 57 | 64 | 61 | 58 | ||
52 | 53 | 53 | 55 | 55 | 59 | 60 | 65 | 56 | ||
55 | 57 | 55 | 56 | 56 | 57 | 62 | 55 | 56 | ||
56 | 53 | 55 | 54 | 58 | 60 | 63 | 61 | 59 | ||
53 | 56 | 58 | 58 | 54 | 57 | 56 | 66 | 58 | ||
56 | 54 | 52 | 59 | 56 | 57 | 53 | 54 | 59 | ||
55 ± .6 | 55 ± .6 | 55 ± .7 | 57 ± .6 | 56 ± .6 | 58 ± .5 | 62 ± 1.5 | 60 ± 1.7 | 59 ± 1.2 | ||
real_protocol | 53 | 52 | 52 | 60 | 56 | 57 | 60 | 58 | 62 | |
58 | 56 | 58 | 54 | 56 | 56 | 57 | 53 | 67 | ||
58 | 57 | 56 | 59 | 54 | 59 | 61 | 58 | 56 | ||
58 | 57 | 55 | 58 | 54 | 59 | 54 | 64 | 55 | ||
53 | 54 | 53 | 60 | 55 | 60 | 61 | 60 | 69 | ||
56 | 52 | 52 | 56 | 60 | 57 | 56 | 53 | 61 | ||
53 | 58 | 57 | 57 | 56 | 60 | 66 | 60 | 64 | ||
52 | 57 | 58 | 58 | 59 | 57 | 58 | 60 | 57 | ||
56 | 56 | 55 | 59 | 54 | 56 | 65 | 67 | 67 | ||
56 | 53 | 52 | 58 | 58 | 59 | 57 | 61 | 57 | ||
55 ± .8 | 55 ± .7 | 54 ± .8 | 57 ± .6 | 56 ± .7 | 58 ± .5 | 59 ± 1.2 | 59 ± 1.4 | 61 ± 1.6 | ||
| ||||||||||
MEP (mV6) | rES_alone | 0.3 | 0.3 | 0.3 | 0.5 | 0.5 | 0.7 | 0.6 | 0.6 | 0.5 |
0.6 | 0.6 | 0.6 | 0.6 | 0.6 | 0.7 | 0.5 | 0.5 | 0.6 | ||
0.9 | 0.9 | 0.9 | 0.6 | 0.6 | 0.6 | 0.4 | 0.5 | 0.5 | ||
0.8 | 0.8 | 0.8 | 0.6 | 0.6 | 0.7 | 0.5 | 0.5 | 0.5 | ||
0.9 | 0.9 | 0.9 | 0.6 | 0.7 | 0.5 | 0.6 | 0.4 | 0.5 | ||
0.9 | 0.9 | 0.9 | 0.7 | 0.6 | 0.6 | 0.6 | 0.5 | 0.5 | ||
0.8 | 0.8 | 0.8 | 0.6 | 0.5 | 0.7 | 0.6 | 0.5 | 0.6 | ||
0.8 | 0.8 | 0.8 | 0.7 | 0.5 | 0.7 | 0.5 | 0.5 | 0.5 | ||
0.8 | 0.8 | 0.8 | 0.6 | 0.5 | 0.5 | 0.5 | 0.6 | 0.5 | ||
0.8 | 0.8 | 0.8 | 0.7 | 0.5 | 0.6 | 0.6 | 0.5 | 0.5 | ||
0.7 ± .1 | 0.7 ± .1 | 0.7 ± .1 | 0.6 ± 0.02 | 0.6 ± 0.02 | 0.6 ± 0.02 | 0.5 ± 0.02 | 0.5 ± 0.02 | 0.5 ± 0.02 | ||
rTMS_alone | 0.3 | 0.3 | 0.3 | 0.7 | 0.5 | 0.7 | 0.5 | 0.5 | 0.6 | |
0.6 | 0.6 | 0.6 | 0.6 | 0.6 | 0.5 | 0.4 | 0.5 | 0.5 | ||
0.9 | 0.9 | 0.9 | 0.7 | 0.5 | 0.7 | 0.6 | 0.5 | 0.5 | ||
0.8 | 0.8 | 0.8 | 0.7 | 0.6 | 0.6 | 0.6 | 0.5 | 0.5 | ||
0.9 | 0.9 | 0.9 | 0.6 | 0.6 | 0.6 | 0.6 | 0.6 | 0.6 | ||
0.9 | 0.9 | 0.9 | 0.5 | 0.6 | 0.6 | 0.6 | 0.6 | 0.4 | ||
0.8 | 0.8 | 0.8 | 0.7 | 0.6 | 0.5 | 0.4 | 0.6 | 0.4 | ||
0.8 | 0.8 | 0.8 | 0.6 | 0.5 | 0.7 | 0.5 | 0.4 | 0.4 | ||
0.8 | 0.8 | 0.8 | 0.6 | 0.6 | 0.5 | 0.5 | 0.6 | 0.4 | ||
0.8 | 0.8 | 0.8 | 0.7 | 0.6 | 0.6 | 0.5 | 0.5 | 0.5 | ||
0.7 ± .1 | 0.7 ± .1 | 0.7 ± .1 | 0.6 ± .1 | 0.6 ± .1 | 0.6 ± .1 | 0.5 ± 0.02 | 0.5 ± 0.02 | 0.5 ± 0.02 | ||
real_protocol | 0.3 | 0.7 | 0.3 | 0.8 | 0.8 | 0.8 | 0.5 | 0.6 | 0.5 | |
0.6 | 0.8 | 0.6 | 0.9 | 0.9 | 0.9 | 0.5 | 0.5 | 0.5 | ||
0.9 | 1.2 | 0.9 | 0.6 | 0.8 | 0.6 | 0.4 | 0.6 | 0.4 | ||
0.8 | 1.0 | 0.8 | 0.8 | 0.9 | 0.8 | 0.6 | 0.4 | 0.4 | ||
0.9 | 1.2 | 0.9 | 0.8 | 0.8 | 0.8 | 0.4 | 0.5 | 0.5 | ||
0.9 | 1.2 | 0.9 | 0.9 | 1 | 0.9 | 0.4 | 0.5 | 0.5 | ||
0.8 | 1.1 | 0.8 | 0.8 | 1 | 0.8 | 0.5 | 0.5 | 0.5 | ||
0.8 | 1.1 | 0.8 | 0.3 | 0.9 | 0.3 | 0.6 | 0.5 | 0.5 | ||
0.8 | 1.2 | 0.8 | 0.8 | 0.8 | 0.8 | 0.5 | 0.5 | 0.4 | ||
0.8 | 1.1 | 0.8 | 0.9 | 1 | 0.9 | 0.5 | 0.5 | 0.6 | ||
0.7 ± .1 | 1.1 ± .1 | 0.7 ± .1 | 0.7 ± .1 | 0.9 ± .05 | 0.7 ± .1 | 0.5 ± 0.02 | 0.5 ± 0.02 | 0.5 ± 0.02 | ||
| ||||||||||
AMI (mV) | rES_alone | 0.5 | 0.4 | 0.3 | 0.6 | 0.5 | 0.5 | 0.6 | 0.5 | 0.5 |
0.3 | 0.5 | 0.4 | 0.4 | 0.5 | 0.5 | 0.4 | 0.5 | 0.5 | ||
0.4 | 0.5 | 0.3 | 0.4 | 0.5 | 0.5 | 0.4 | 0.5 | 0.5 | ||
0.5 | 0.3 | 0.4 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | ||
0.5 | 0.5 | 0.3 | 0.4 | 0.6 | 0.5 | 0.4 | 0.6 | 0.5 | ||
0.5 | 0.3 | 0.4 | 0.5 | 0.4 | 0.5 | 0.5 | 0.4 | 0.5 | ||
0.3 | 0.3 | 0.4 | 0.4 | 0.5 | 0.6 | 0.4 | 0.5 | 0.6 | ||
0.5 | 0.4 | 0.3 | 0.5 | 0.5 | 0.4 | 0.5 | 0.5 | 0.4 | ||
0.3 | 0.4 | 0.3 | 0.5 | 0.6 | 0.4 | 0.5 | 0.6 | 0.4 | ||
0.5 | 0.4 | 0.3 | 0.5 | 0.4 | 0.4 | 0.5 | 0.4 | 0.4 | ||
0.4 ± 0.02 | 0.4 ± 0.02 | 0.4 ± 0.02 | 0.5 ± 0.02 | 0.5 ± 0.02 | 0.5 ± 0.02 | 0.5 ± 0.02 | 0.5 ± 0.02 | 0.5 ± 0.02 | ||
rTMS_alone | 0.5 | 0.3 | 0.4 | 0.5 | 0.4 | 0.5 | 0.5 | 0.4 | 0.5 | |
0.5 | 0.4 | 0.4 | 0.5 | 0.5 | 0.6 | 0.5 | 0.5 | 0.6 | ||
0.4 | 0.3 | 0.3 | 0.5 | 0.6 | 0.5 | 0.5 | 0.6 | 0.5 | ||
0.3 | 0.3 | 0.4 | 0.5 | 0.4 | 0.5 | 0.5 | 0.4 | 0.5 | ||
0.3 | 0.5 | 0.4 | 0.6 | 0.4 | 0.6 | 0.6 | 0.4 | 0.6 | ||
0.3 | 0.3 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | ||
0.3 | 0.3 | 0.4 | 0.5 | 0.5 | 0.4 | 0.5 | 0.5 | 0.4 | ||
0.4 | 0.3 | 0.3 | 0.4 | 0.5 | 0.5 | 0.4 | 0.5 | 0.5 | ||
0.4 | 0.3 | 0.5 | 0.6 | 0.5 | 0.5 | 0.6 | 0.5 | 0.5 | ||
0.4 | 0.4 | 0.5 | 0.6 | 0.5 | 0.5 | 0.6 | 0.5 | 0.5 | ||
0.4 ± 0.02 | 0.4 ± 0.01 | 0.4 ± 0.02 | 0.5 ± 0.02 | 0.5 ± 0.02 | 0.5 ± 0.02 | 0.5 ± 0.02 | 0.5 ± 0.02 | 0.5 ± 0.02 | ||
real_protocol | 0.5 | 0.9 | 0.4 | 0.6 | 0.3 | 0.5 | 0.6 | 0.4 | 0.6 | |
0.4 | 1 | 0.3 | 0.4 | 0.6 | 0.4 | 0.5 | 0.4 | 0.5 | ||
0.3 | 1 | 0.4 | 0.6 | 0.9 | 0.5 | 0.5 | 0.4 | 0.4 | ||
0.3 | 0.8 | 0.5 | 0.5 | 0.8 | 0.5 | 0.6 | 0.6 | 0.6 | ||
0.4 | 0.9 | 0.5 | 0.4 | 0.9 | 0.4 | 0.5 | 0.6 | 0.5 | ||
0.5 | 0.8 | 0.3 | 0.5 | 0.9 | 0.6 | 0.6 | 0.5 | 0.4 | ||
0.4 | 0.8 | 0.4 | 0.4 | 0.8 | 0.5 | 0.4 | 0.5 | 0.5 | ||
0.4 | 0.9 | 0.4 | 0.5 | 0.8 | 0.6 | 0.5 | 0.5 | 0.5 | ||
0.5 | 1 | 0.4 | 0.4 | 0.8 | 0.6 | 0.5 | 0.5 | 0.5 | ||
0.4 | 0.8 | 0.5 | 0.4 | 0.8 | 0.5 | 0.5 | 0.6 | 0.6 | ||
0.4 ± .03 | 0.9 ± .05 | 0.4 ± .02 | 0.5 ± 0.5 | 0.7 ± .1 | 0.5 ± 0.02 | 0.5 ± 0.02 | 0.5 ± 0.02 | 0.5 ± 0.02 | ||
| ||||||||||
LLAEP amplitude (μV) | rES_alone | 16 | 3 | 7 | 7 | 11 | 11 | 5 | 0 | 2 |
6 | 4 | 2 | 11 | 11 | 7 | 4 | 2 | 5 | ||
3 | 6 | 7 | 10 | 10 | 13 | 0 | 7 | 1 | ||
14 | 1 | 8 | 11 | 9 | 6 | 7 | 6 | 2 | ||
2 | 3 | 6 | 6 | 12 | 5 | 2 | 0 | 0 | ||
9 | 10 | 15 | 5 | 11 | 8 | 6 | 7 | 2 | ||
16 | 8 | 15 | 12 | 7 | 12 | 6 | 7 | 6 | ||
10 | 12 | 11 | 12 | 5 | 5 | 5 | 1 | 4 | ||
1 | 5 | 16 | 5 | 13 | 9 | 6 | 6 | 2 | ||
9 | 3 | 16 | 8 | 6 | 10 | 5 | 2 | 6 | ||
9 ± 1 | 6 ± 2 | 10 ± 2 | 9 ± 1 | 10 ± 1 | 9 ± 1 | 5 ± 1 | 4 ± 0.4 | 3 ± 1 | ||
rTMS_alone | 16 | 0 | 2 | 12 | 8 | 7 | 2 | 1 | 7 | |
7 | 10 | 7 | 13 | 13 | 6 | 3 | 1 | 4 | ||
7 | 6 | 8 | 12 | 11 | 8 | 7 | 7 | 6 | ||
16 | 15 | 10 | 5 | 11 | 5 | 2 | 7 | 4 | ||
14 | 1 | 0 | 8 | 9 | 11 | 4 | 7 | 6 | ||
16 | 8 | 4 | 12 | 8 | 7 | 4 | 6 | 2 | ||
5 | 10 | 11 | 6 | 11 | 13 | 5 | 7 | 4 | ||
5 | 16 | 13 | 5 | 13 | 10 | 6 | 1 | 5 | ||
15 | 9 | 5 | 6 | 9 | 10 | 3 | 4 | 0 | ||
1 | 2 | 2 | 7 | 13 | 13 | 2 | 1 | 4 | ||
10 ± 2 | 8 ± 2 | 6 ± .4 | 9 ± 1 | 11 ± 1 | 9 ± 1 | 4 ± 1 | 4 ± 1 | 4 ± 1 | ||
real_protocol | 12 | 3 | 13 | 9 | 9 | 11 | 0 | 0 | 2 | |
16 | 5 | 6 | 9 | 9 | 7 | 0 | 1 | 4 | ||
6 | 6 | 6 | 12 | 12 | 10 | 7 | 4 | 5 | ||
3 | 16 | 2 | 13 | 11 | 8 | 6 | 2 | 2 | ||
12 | 10 | 2 | 7 | 9 | 12 | 7 | 3 | 6 | ||
4 | 7 | 16 | 11 | 6 | 5 | 2 | 4 | 3 | ||
6 | 11 | 10 | 10 | 5 | 9 | 4 | 5 | 6 | ||
14 | 15 | 8 | 13 | 11 | 13 | 3 | 2 | 2 | ||
3 | 3 | 14 | 10 | 11 | 6 | 3 | 5 | 6 | ||
4 | 14 | 6 | 9 | 5 | 7 | 5 | 6 | 4 | ||
8 ± 2 | 9 ± 1 | 8 ± 1 | 10 ± .4 | 9 ± 1 | 9 ± 1 | 4 ± .4 | 3 ± 1 | 4 ± 1 | ||
| ||||||||||
LLAEP latency (ms) | rES_alone | 89 | 124 | 100 | 111 | 118 | 114 | 131 | 124 | 123 |
81 | 95 | 90 | 98 | 117 | 126 | 162 | 135 | 125 | ||
95 | 127 | 133 | 95 | 115 | 131 | 117 | 118 | 106 | ||
84 | 97 | 110 | 110 | 147 | 135 | 162 | 163 | 121 | ||
89 | 96 | 127 | 111 | 145 | 114 | 161 | 161 | 119 | ||
95 | 105 | 126 | 110 | 130 | 151 | 164 | 126 | 122 | ||
82 | 110 | 88 | 109 | 140 | 140 | 139 | 138 | 110 | ||
79 | 84 | 103 | 102 | 107 | 115 | 130 | 140 | 107 | ||
91 | 109 | 105 | 108 | 132 | 143 | 138 | 133 | 106 | ||
86 | 94 | 103 | 101 | 136 | 128 | 116 | 148 | 108 | ||
87 ± 2 | 104 ± 4 | 109 ± 5 | 106 ± 2 | 129 ± 4 | 130 ± 4 | 142 ± 3 | 138 ± 5 | 115 ± 6 | ||
rTMS_alone | 89 | 109 | 97 | 113 | 111 | 133 | 126 | 123 | 124 | |
81 | 86 | 82 | 103 | 98 | 111 | 171 | 125 | 157 | ||
95 | 130 | 106 | 103 | 95 | 105 | 135 | 106 | 146 | ||
84 | 107 | 89 | 148 | 110 | 126 | 132 | 121 | 153 | ||
89 | 95 | 117 | 122 | 111 | 111 | 166 | 119 | 129 | ||
95 | 119 | 104 | 110 | 110 | 115 | 142 | 122 | 147 | ||
82 | 95 | 107 | 132 | 109 | 117 | 146 | 110 | 134 | ||
79 | 104 | 84 | 131 | 102 | 114 | 131 | 107 | 127 | ||
91 | 113 | 105 | 138 | 108 | 128 | 145 | 106 | 126 | ||
86 | 109 | 100 | 135 | 101 | 108 | 113 | 108 | 110 | ||
87 ± 2 | 107 ± 4 | 99 ± 4 | 123 ± 2 | 106 ± 5 | 117 ± 3 | 141 ± 3 | 115 ± 6 | 135 ± 5 | ||
real_protocol | 89 | 116 | 117 | 155 | 119 | 111 | 128 | 137 | 159 | |
81 | 97 | 90 | 124 | 122 | 98 | 106 | 146 | 139 | ||
95 | 96 | 114 | 102 | 110 | 95 | 133 | 110 | 121 | ||
84 | 86 | 96 | 135 | 107 | 110 | 147 | 126 | 128 | ||
89 | 120 | 111 | 139 | 106 | 111 | 142 | 140 | 119 | ||
95 | 121 | 124 | 135 | 122 | 110 | 132 | 146 | 168 | ||
82 | 108 | 106 | 111 | 110 | 109 | 132 | 153 | 125 | ||
79 | 86 | 94 | 103 | 107 | 102 | 103 | 119 | 109 | ||
91 | 97 | 116 | 116 | 106 | 108 | 150 | 123 | 110 | ||
86 | 105 | 97 | 117 | 108 | 101 | 126 | 115 | 132 | ||
87 ± 2 | 103 ± 4 | 106 ± 4 | 124 ± 2 | 112 ± 5 | 106 ± 5 | 130 ± 2 | 132 ± 5 | 131 ± 6 |