Table 1.

Top 5 canonical pathways in pediatric septic shock vs. controls

Pathway name	Number of genes	Percentage of genes upregulated in patients with septic shock vs. controls
Nrf2 mediated oxidative stress response	24	79 %
Xenobiotic metabolism signaling	25	76 %
LPS/IL-1 mediated inhibition of RXR function	23	61 %
Aryl hydrocarbon receptor signaling	17	59 %
Glutathione redox reactions I	8	88 %

Abbreviations: IL interleukin, LPS lipopolysaccharide, Nrf2 nuclear erythroid-related factor 2 p45-related factor 2, RXR retinoic acid receptor