Table 1.
The tag SNPs of KCNB1 associated with lipid metabolism and insulin resistance
| Genotype | M/F | Age | BMI | WHR | TC | TG | HDL-C | LDL-C | FPG | FINS | HOMA-IR | HOMA-B | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs16994565 | TT | 267/341 | 39.68 ± 10.05 | 23.10 ± 2.48 | 0.80 ± 0.07 | 4.60 ± 0.84 | 1.11 ± 0.61 | 1.67 ± 0.34 | 2.67 ± 0.71 | 4.94 ± 0.48 | 8.91 ± 3.29 | 1.15 ± 0.42 | 108.58 ± 32.51 |
| TC | 40/66 | 39.91 ± 11.26 | 22.95 ± 2.73 | 079 ± 0.07 | 4.46 ± 0.80 | 1.02 ± 0.57 | 1.66 ± 0.30 | 2.54 ± 0.67 | 4.90 ± 0.47 | 8.88 ± 3.26 | 1.14 ± 0.42 | 109.46 ± 30.33 | |
| CC | 3/4 | 36.00 ± 9.52 | 22.39 ± 2.90 | 0.77 ± 0.07 | 3.75 ± 1.71 | 0.98 ± 0.31 | 1.64 ± 0.25 | 2.49 ± 0.34 | 4.85 ± 0.33 | 8.63 ± 1.09 | 1.10 ± 0.15 | 110.49 ± 19.00 | |
| P 1 | 0.5 | 0.62 | 0.67 | 0.51 | 0.01 | 0.31 | 0.95 | 0.18 | 0.75 | 0.97 | 0.95 | 0.82 | |
| P 2(TC vs CC) | 0.83,0.21(-1.71,2.13) | 0.23,0.02(-0.01,0.06) | 0.08,0.58(-0.06,1.23) | 0.99,0.001(-0.39,0.39) | 0.90,-0.01(-0.22,0.20) | 0.95,-0.01(-0.50,0,48) | 0.84,-0.03(-0.35,0.29) | 0.81,0.31(-2.17,2.79) | 0.78,-0.05(-0.28,0.37) | 0.80,2.81(-19.05,24.67) | |||
| P 2(TT vs CC) | 0.60,0.23(-0.62,1.08) | 0.24,0.01(-0.01,0.03) | 0.02,0.36(0.06,0.66) | 0.74,0.03(-0.17,0.24) | 0.93,0.01(-0.11,0.12) | 0.73,0.04(-0.20,0.29) | 0.91,0.01(-0.16,0.17) | 0.78,0.18(-1.04,1.39) | 0.73,0.03(-0.13,0.18) | 0.92,0.64(-11.04,12.31) | |||
| rs237460 | GG | 101/128 | 39.34 ± 10.39 | 22.92 ± 2.58 | 0.795 ± 0.07 | 4.51 ± 0.91 | 1.07 ± 0.56 | 1.66 ± 0.30 | 2.64 ± 0.73 | 4.91 ± 0.47 | 8.63 ± 3.26 | 1.11 ± 0.42 | 106.55 ± 29.15 |
| GA | 157/204 | 39.85 ± 10.20 | 23.13 ± 2.52 | 0.798 ± 0.07 | 4.55 ± 0.82 | 1.11 ± 0.60 | 1.65 ± 0.34 | 2.60 ± 0.69 | 4.94 ± 0.48 | 9.00 ± 3.25 | 1.16 ± 0.42 | 109.16 ± 32.36 | |
| AA | 53/80 | 40.09 ± 10.36 | 23.20 ± 2.45 | 0.796 ± 0.07 | 4.73 ± 0.80 | 1.12 ± 0.64 | 1.72 ± 0.34 | 2.78 ± 0.69 | 4.94 ± 0.46 | 9.11 ± 3.34 | 1.17 ± 0.42 | 110.98 ± 35.76 | |
| P 1 | 0.71 | 0.77 | 0.52 | 0.87 | 0.04 | 0.67 | 0.13 | 0.06 | 0.82 | 0.29 | 0.33 | 0.24 | |
| P 2(GA vs AA) | 0.66,-0.10(-0.56,0.36) | 0.89,-0.001(-0.01,0.01) | 0.02,-0.19(-0.34,-0.04) | 0.62,-0.03(-0.14,0.08) | 0.07,-0.06(-0.12,0.01) | 0.005,-0.18(-0.31,-0.06) | 0.98,-0.001(-0.09,0.09) | 0.66,-0.15(-0.79.0.50) | 0.75,-0.01(-0.10,0.07) | 0.49,-2.23(-8.63,4.17) | |||
| P 2(GG vs AA) | 0.26,-0.14(-0.39,0.11) | 0.51,-0.002(-0.01,0.003) | 0.02,-0.11(-0.19,-0.02) | 0.31,-0.03(-0.09,0.03) | 0.15,-0.02(-0.06,0.10) | 0.07,-0.07(-0.14,0.004) | 0.73,-0.01(-0.06,0.04) | 0.15,-0.26(-0.61,0.10) | 0.19-,0.03(-0.08,0.02) | 0.13,-2.53(-5.82,0.77) | |||
| rs3331 | TT | 270/348 | 39.48 ± 10.06 | 23.08 ± 2.51 | 0.80 ± 0.07 | 4.59 ± 0.84 | 1.11 ± 0.60 | 1.67 ± 0.34 | 2.66 ± 0.71 | 4.93 ± 0.48 | 8.90 ± 3.28 | 1.15 ± 0.42 | 108.53 ± 32.33 |
| TC | 40/59 | 41.15 ± 11.36 | 23.08 ± 2.61 | 0.80 ± 0.06 | 4.48 ± 0.79 | 1.03 ± 0.59 | 1.63 ± 0.27 | 2.57 ± 0.68 | 4.91 ± 0.46 | 8.97 ± 3.29 | 1.15 ± 0.43 | 110.04 ± 30.98 | |
| CC | 1/4 | 39.2 ± 11.48 | 22.64 ± 3.22 | 0.76 ± 0.06 | 3.57 ± 2.05 | 0.94 ± 0.33 | 1.69 ± 0.15 | 2.58 ± 0.38 | 4.85 ± 0.25 | 7.94 ± 1.16 | 1.02 ± 0.16 | 104.26 ± 17.80 | |
| P 1 | 0.48 | 0.32 | 0.93 | 0.31 | 0.02 | 0.42 | 0.71 | 0.47 | 0.8 | 0.79 | 0.78 | 0.97 | |
| P 2(TC vs CC) | 0.96,0.06(-2.11,2.24) | 0.22,0.03(-0.02,0.07) | 0.03,0.83(0.09,1.57) | 0.94,-0.02(-0.50,0.47) | 0.83,-0.03(-0.25,0.20) | 0.73,-0.10(-0.68,0.48) | 0.82,0.04(-0.33,0.42) | 0.55,0.90(-2.07,3.87) | 0.54,0.12(-0.27,0.51) | 0.69,5.43(21.04,31.89) | |||
| P 2 (TT vs CC) | 0.95,0.03(-0.99,1.05) | 0.43,0.01(-0.01,0.03) | 0.01,0.49(0.13,0.84) | 0.79,0.03(-0.21,0.27) | 0.81,0.02(-0.12,0.16) | 0.97,-0.01(-0.29,0.28) | 0.80,0.03(-0.17,0.22) | 0.58,0.40(-1.03,1.84) | 0.57,0.05(-0.13,0.24) | 0.77,2.08(-11.64,15.80) | |||
| rs802950 | CC | 212/276 | 39.63 ± 10.27 | 23.09 ± 2.52 | 0.80 ± 0.07 | 4.60 ± 0.86 | 1.12 ± 0.60 | 1.67 ± 0.33 | 2.67 ± 0.71 | 4.92 ± 0.48 | 8.85 ± 3.29 | 1.14 ± 0.42 | 108.67 ± 31.87 |
| AC | 89/118 | 39.58 ± 10.25 | 23.06 ± 2.52 | 0.79 ± 0.07 | 4.47 ± 0.84 | 1.05 ± 0.58 | 1.64 ± 0.33 | 2.58 ± 0.69 | 4.96 ± 0.49 | 9.03 ± 3.21 | 1.17 ± 0.41 | 108.84 ± 32.97 | |
| AA | 10/19 | 42.45 ± 10.06 | 22.96 ± 2.61 | 0.80 ± 0.06 | 4.90 ± 0.85 | 1.12 ± 0.73 | 1.79 ± 029 | 2.79 ± 0.68 | 4.94 ± 0.35 | 9.02 ± 3.39 | 1.16 ± 0.44 | 108.07 ± 29.56 | |
| P 1 | 0.64 | 0.35 | 0.96 | 0.29 | 0.02 | 0.44 | 0.07 | 0.18 | 0.58 | 0.79 | 0.75 | 0.58 | |
| P 2(AC vs AA) | 0.69,0.18(-0.71,1.07) | 0.32,-0.01(-0.03,0.01) | 0.03,-0.36(-0.68,-0.05) | 0.56,-0.06(-0.28,0.15) | 0.06,-0.12(-0.24,0.01) | 0.14,-0.19(-0.45,0.06) | 0.36,0.08(-0.09,0.24) | 0.98,-0.02(-1.29,1.25) | 0.93,0.01(-0.16,0.17) | 0.78,-1.77(-14.19,10.66) | |||
| P 2(CC vs AA) | 0.65,0.10(-0.34,0.54) | 0.88,0.001(-0.01.0.01) | 0.17,-0.11(-0.26,0.05) | 0.99,0.001(-0.11,0.11) | 0.12,-0.05(-0.11,0.01) | 0.61,-0.03(-0.16,0.09) | 0.85,0.01(-0.08,0.09) | 0.61,-0.16(-0.77,0.46) | 0.66,-0.02(-0.10,0.06) | 0.72,-1.06(-6.79,4.67) | |||
| rs926672 | AA | 97/145 | 39.66 ± 10.39 | 22.91 ± 2.43 | 0.80 ± 0.07 | 4.57 ± 0.90 | 1.10 ± 0.58 | 1.69 ± 0.35 | 2.63 ± 0.74 | 4.93 ± 0.44 | 8.66 ± 3.15 | 1.12 ± 0.41 | 106.19 ± 29.59 |
| AT | 165/190 | 39.69 ± 10.29 | 23.28 ± 2.61 | 0.80 ± 0.07 | 4.61 ± 0.81 | 1.15 ± 0.65 | 1.65 ± 0.32 | 2.68 ± 0.69 | 4.94 ± 0.51 | 9.23 ± 3.41 | 1.19 ± 0.44 | 111.47 ± 34.21 | |
| TT | 48/76 | 39.89 ± 10.00 | 23.78 ± 2.42 | 0.79 ± 0.07 | 4.44 ± 0.86 | 0.94 ± 0.45 | 1.66 ± 0.31 | 2.61 ± 0.65 | 4.91 ± 0.43 | 8.43 ± 3.01 | 1.08 ± 0.39 | 105.49 ± 29.76 | |
| P 1 | 0.17 | 0.98 | 0.08 | 0.21 | 0.19 | 0.004 | 0.44 | 0.53 | 0.83 | 0.02 | 0.02 | 0.07 | |
| P 2(AT vs TT) | 0.13,0.38(-0.11,0.88) | 0.17,0.01(-0.003,0.02) | 0.049,0.16(0.00,0.32) | 0.002,0.19(0.07,0.30) | 0.90,0.004(-0.06,0.07) | 0.46,0.05(-0.08,0.18) | 0.62,0.02(-0.07,0.12) | 0.03,0.74(0.06,1,42) | 0.02,0.10(0.01,0.19) | 0.09,5.66(-0.86,12.18) | |||
| P 2(AA vs TT) | 0.60,0.07(-0.18,0.31) | 0.15,0.004(-0.001,0.01) | 0.16,0.06(-0.13,0.16) | 0.004,0.08(0.02,0.13) | 0.46,0.01(-0.02,0.05) | 0.75,0.01(-0.06,0.08) | 0.62,0.01(-0.03,0.06) | 0.53,0.11(-0.23,0.44) | 0.45,0.02(-0.03,0.06) | 0.88,0.24(-2.83,3.31) | |||
| rs1051295 | TT | 111/147 | 39.96 ± 10.82 | 22.97 ± 2.50 | 0.80 ± 0.07 | 4.65 ± 0.92 | 1.13 ± 0.58 | 1.67 ± 0.35 | 2.71 ± 0.80 | 4.93 ± 0.51 | 9.08 ± 3.34 | 1.17 ± 0.43 | 110.43 ± 33.11 |
| TC | 153/203 | 40.33 ± 10.16 | 23.10 ± 2.50 | 0.79 ± 0.07 | 4.54 ± 0.83 | 1.12 ± 0.65 | 1.66 ± 0.34 | 2.63 ± 0.64 | 4.94 ± 0.44 | 8.95 ± 3.26 | 1.15 ± 0.42 | 108.35 ± 31.32 | |
| CC | 51/68 | 38.3 ± 9.81 | 23.29 ± 2.66 | 0.79 ± 0.07 | 4.49 ± 0.73 | 0.99 ± 0.45 | 1.68 ± 0.28 | 2.61 ± 0.67 | 4.93 ± 0.50 | 8.52 ± 3.06 | 1.10 ± 0.39 | 105.98 ± 31.02 | |
| P 1 | 1 | 0.18 | 0.51 | 0.42 | 0.13 | 0.08 | 0.76 | 0.22 | 0.9 | 0.29 | 0.24 | 0.44 | |
| P 2(TC vs CC) | 0.16,-0.35(-0.83,0.13) | 0.42,-0.004(-0.01,001) | 0.88,0.11(-0.15,0.18) | 0.10,0.10(-002,0.22) | 0.51,-0.02(-0.09,0.04) | 0.78,-0.02(-0.14,0.11) | 0.73,-0.02(-0.11,0.07) | 0.16,0.48(-0.19,1.15) | 0.16,0.06(-0.03,0.15) | 0.21,4.07(-2.23,10.36) | |||
| P 2(TT vs CC) | 0.09,-0.22(-0.48,0.04) | 0.60,0.001(-0.004,0.01) | 0.19,0.06(-0.03,0.15) | 0.03,0.06(0.01,0.12) | 0.66,-0.01(-0.04,0.03) | 0.39,0.03(-0.04,0.11) | 0.49,-0.02(-0.07,0.03) | 0.11,2.92(-0.06,0.65) | 0.09,0.04(-0.01,0.09) | 0.09,2.96(-0.45,6.36) | |||
| rs2057077 | CC | 102/160 | 39.42 ± 10.30 | 22.89 ± 2.52 | 0.79 ± 0.07 | 4.55 ± 0.92 | 1.07 ± 0.58 | 1.67 ± 0.33 | 2.62 ± 0.72 | 4.93 ± 0.45 | 8.64 ± 3.18 | 1.11 ± 0.41 | 105.91 ± 28.55 |
| TC | 170/193 | 39.74 ± 10.28 | 23.22 ± 2.58 | 0.80 ± 0.07 | 4.58 ± 0.82 | 1.13 ± 0.61 | 1.65 ± 0.33 | 2.68 ± 0.69 | 4.94 ± 0.48 | 9.26 ± 3.36 | 1.19 ± 0.43 | 111.55 ± 34.05 | |
| TT | 40/60 | 40.71 ± 10.32 | 23.04 ± 2.27 | 0.79 ± 0.07 | 4.59 ± 0.80 | 1.04 ± 0.60 | 1.67 ± 0.33 | 2.66 ± 0.72 | 4.90 ± 0.51 | 8.29 ± 3.03 | 1.06 ± 0.39 | 105.53 ± 32.51 | |
| P 1 | 0.12 | 0.57 | 0.26 | 0.52 | 0.91 | 0.25 | 0.73 | 0.59 | 0.76 | 0.01 | 0.005 | 0.02 | |
| P 2(TC vs TT) | 0.60,0.14(-0.39,0.67) | 0.86,0.001(-0.01,0.01) | 0.88,0.01(-0.16,0.18) | 0.19,0.08(-0.04,0.21) | 0.96,0.002(-0.07,0.07) | 0.83,0.03(-0.13,0.16) | 0.36,0.05(-0.05,0.15) | 0.01,0.92(0.19,1.65) | 0.008,0.13(0.03,0.23) | 0.17,5.06(-2.17,12.29) | |||
| P 2(CC vs TT) | 0.83,-0.03(-0.29,0.24) | 0.51,0.002(-0.004,0.01) | 0.90,0.006(-0.09,0.10) | 0.31,0.03(-0.03,0.09) | 0.95,0.001(-0.03,0.04) | 0.95,-0.003(-0.08,0.07) | 0.27,0.03(-0.02,0.08) | 0.36,0.17(-0.19,0.53) | 0.29,0.03(-0.02,0.72) | 0.83,-0.35(-3.63,2.92) | |||
| rs4810952 | TT | 81/126 | 39.43 ± 10.15 | 22.97 ± 2.46 | 0.79 ± 0.07 | 4.58 ± 0.89 | 1.08 ± 0.58 | 1.68 ± 0.34 | 2.65 ± 0.73 | 4.94 ± 0.43 | 8.40 ± 3.18 | 1.10 ± 0.41 | 103.09 ± 28.72 |
| TC | 170/194 | 39.82 ± 10.33 | 23.16 ± 2.61 | 0.80 ± 0.07 | 4.59 ± 0.82 | 1.14 ± 0.62 | 1.66 ± 0.33 | 2.66 ± 0.71 | 4.93 ± 0.50 | 9.30 ± 3.37 | 1.20 ± 0.43 | 112.54 ± 34.05 | |
| CC | 60/91 | 39,79 ± 10.27 | 23.02 ± 2.40 | 0.79 ± 0.06 | 4.59 ± 0.87 | 1.02 ± 0.57 | 1.65 ± 0.31 | 2.61 ± 0.64 | 4.92 ± 0.46 | 8.62 ± 3.04 | 1.11 ± 0.39 | 107.17 ± 30.30 | |
| P 1 | 0.14 | 0.9 | 0.67 | 0.25 | 0.56 | 0.11 | 0.56 | 0.76 | 0.88 | 0.004 | 0.004 | 0.01 | |
| P 2(TC vs TT) | 0.91,0.03(-0.38,0.43) | 0.87,-0.001(-0.01,0.01) | 0.85,-0.01(-0.15,0.13) | 0.61,0.03(-0.07,0.12) | 0.78,-0.01(-0.06,0.05) | 0.74,-0.02(-0.14,0.10) | 0.41,-0.03(-0.11,0.04) | 0.003,0.86(0.30,1.43) | 0.004,0.11(0.04,0.18) | <0.001,9.60(4.27,14.93) | |||
| P 2(CC vs TT) | 0.93,0.01(-0.23,0.25) | 0.52,-0.002(-0.01,0.003) | 0.30,-0.05(-0.13,0.04) | 0.26,-0.03(-0.09,0.02) | 0.30,-0.02(-0.06,0.02) | 0.52,-0.02(-0.09,0.05) | 0.50,-0.02(-0.06,0.03) | 0.48,0.12(-0.21,0.44) | 0.59,0.01(-0.03,0.06) | 0.15,2.18(-0.79,5.16) |
Data are present as mean ± SD, M/F male/female, WHR Waist to hip ratio, TG triglycerides, TC serum total cholesterol, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, FPG fasting plasma glucose, FINS fasting serum insulin, P 1 from one-way ANOVA test except P 1for M/F from χ 2 test, P 2 from multiple linear regression analysis with b and 95 % CIs (adjusted for age and gender)