Fig 4. KV11.1 channel rectification and voltage dependence of inactivation.
(A) Representative recordings of equine (n = 10) and human KV11.1 (n = 10) expressed in Xenopus laevis oocytes. (B) Fully activated current-voltage (I-V) relationship of the equine and human KV11.1 channels. The maximal conductance (G) of the tail currents was determined as the slope of a linear fit to maximal tail current amplitudes at potential between -120 to -90 mV. (C) Voltage dependence of rapid inactivation of equine and human Kv11.1. The rectification factor (R) at each potential was calculated using the current amplitudes plotted in Panel (B) (see Methods for calculation). Data were fitted with a Boltzmann equation.