Fig 8. Equine KV11.1 channels are blocked by terfenadine.
Equine (n = 4) KV11.1 expressed in Xenopus laevis oocytes. Currents were activated by a repeated depolarization to 0 mV from a holding of -80 mV. (A) Representative recordings in control and in the presence of 0.01, 0.03, 0.1, 0.3, 1, 3 and 10 μM terfenadine. Currents got successively smaller as concentrations were increased. (B) Dose-response for the effect of terfenadine on the equine KV11.1 steady-state currents at the end of a depolarizing step to 0 mV. (C) Dose-response for the effect of terfenadine on the equine KV11.1 peak tail current after repolarization from 0 mV to -80 mV. KV11.1 currents are expressed as a fractional value (I drug/I control). On the X-axis values non-transformed values are shown. A non-linear regression was fitted to the data.