Fig. 6.

Model depicting differential occupancies of histone modifications regulating transcription of P. falciparum genes. Active (a) and inactive (b) genes exhibit similar profiles of histone modifications with H3K4me3 and H3K9ac as dominant marks across the gene body. On inactive genes slight increase in the levels of H3K36me2 and decrease in the levels of H3K4me3 and H3K9ac leads to alteration in the ratio of activation to repression mark, which affects gene expression. c Clonally variant multicopy (CVM) genes have different chromatin modifications. On CVM genes, most prominent activation and repression marks are H4ac and H3K9me3, respectively