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. 2015 Sep 16;10(9):e0138384. doi: 10.1371/journal.pone.0138384

Fig 5. Enhancement of cell proliferation by a calcimimetic in PASMCs from IPAH patients.

Fig 5

The effects of R568, a calcimimetic or positive allosteric regulator of CaSR, on cell proliferation were examined in normal, IPAH, and CTEPH PASMCs. Summarized data (a) show the effect of R568 on the cell viability in the concentration range between 100 nM and 10 μM in normal (A), IPAH (B), and CTEPH (C) PASMCs. Dose-response curve (b) of cell proliferation at 48 h for R568 in normal (A), IPAH (B), and CTEPH (C) PASMCs. The absorbance at several concentrations of R568 was normalized by the value in the absence of R568 (as 100%). The EC50 value of R568 for the proliferation of IPAH-PASMCs was 0.33 μM and the Hill coefficient was 2.10. Data were obtained from 5~11 experiments. *p<0.05 or **p<0.01 vs. control (100%).