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. 2015 Sep 17;17:128. doi: 10.1186/s13058-015-0630-z

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© Elsarraj et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Analysis of RNA sequencing data of tandem lesions for BCL9 expression comparing DCIS to invasive ductal carcinoma. Radiographic (a) and H&E stain (b, c) images of a patient’s DCIS/IDC tandem lesion. a Three-dimensional ultrasound image of a tandem lesion. b H&E staining of a biopsy taken from the DCIS and (c) the IDC regions. Insets: lower magnification in b, c, respectively, demonstrating that the biopsies were highly pure and composed of either DCIS or IDC. d, e Normalized log2 transformed expression of BCL9 was plotted and tandem lesions between paired DCIS and IDC are connected by a line to indicate their relationship. The results indicate a significant increase in BCL9 expression in IDC samples compared to the DCIS lesions (p = 0.01)