Table 2.
Numbers of serum peptidome components with abundances different between compared groups of individuals
| Groups/differences | Control vs. cancer (all cases) | Locally advanced vs. metastatic cancer | Local/no spread vs. metastatic cancer | Local/spread vs. metastatic cancer | Local/no spread vs. local/spread cancer |
|---|---|---|---|---|---|
| n | 50 vs. 53 | 35 vs. 18 | 19 vs. 18 | 16 vs. 18 | 19 vs. 16 |
| p < 0.05 | 182 | 88 | 74 | 75 | 11 |
| FDR | 7 % | 14 % | 17 % | 17 % | 100 % |
| p < 0.05/Bonferroni | 101 | 23 | 11 | 16 | 0 |
| AUC (SVM) | 0.94 | 0.91 | 0.92 | 0.97 | 0.48 |
Shown are numbers of differentiating components that reached threshold of statistical significance p = 0.05 (with corresponding FDR estimation) or threshold strengthened with the Bonferroni correction, and power of SVM classifier built of peptidome components (characterized by the AUC value)