Table 3.
Differentiating serum proteins
| Protein name | Protein full name | Gene name | Control/cancer | Local/metastatic | ||
|---|---|---|---|---|---|---|
| Ratio | p value | Ratio | p value | |||
| A1AG1 | Alpha-1-acid glycoprotein 1 | ORM1 | 0.67 | 0.0008 | 1.00 | 0.5824 |
| A1AG2 | Alpha-1-acid glycoprotein 2 | ORM2 | 0.68 | 0.0006 | 1.00 | 0.7414 |
| A1AT | Alpha-1-antitrypsin | SERPINA1 | 0.50 | <0.0001 | 1.03 | 0.6441 |
| A1BG | Alpha-1B-glycoprotein | A1BG | 0.76 | 0.0072 | 1.04 | 0.5824 |
| A2GL | Leucine-rich alpha-2-glycoprotein | LRG1 | 0.46 | 0.0016 | 0.80 | 0.4414 |
| AACT | Alpha-1-antichymotrypsin | SERPINA3 | 0.54 | 0.0007 | 0.97 | 0.9124 |
| ADIPO | Adiponectin | ADIPOQ | 0.41 | 0.0092 | 1.60 | 0.3442 |
| AFAM | Afamin | AFM | 1.30 | 0.0355 | 1.06 | 0.5824 |
| ANGI | Angiogenin | ANG | 0.30 | 0.0465 | 0.24 | 0.0294 |
| APOA1 | Apolipoprotein A-I | APOA1 | 0.47 | <0.0001 | 1.31 | 0.0235 |
| APOC1 | Apolipoprotein C-I | APOC1 | 0.25 | <0.0001 | 1.52 | 0.1183 |
| APOC3 | Apolipoprotein C-III | APOC3 | 1.82 | 0.0108 | 1.20 | 0.5824 |
| APOE | Apolipoprotein E | APOE | 0.62 | 0.0040 | 1.01 | 0.6441 |
| APOF | Apolipoprotein F | APOF | 0.64 | 0.0085 | 0.80 | 0.5235 |
| APOM | Apolipoprotein M | APOM | 0.92 | 0.4275 | 1.51 | 0.0263 |
| C1S | Complement C1s subcomponent | C1S | 0.70 | 0.0016 | 1.22 | 0.0748 |
| CAH1 | Carbonic anhydrase 1 | CA1 | 2.96 | 0.0173 | 2.41 | 0.0143 |
| CBG | Corticosteroid-binding globulin | SERPINA6 | 0.53 | 0.0117 | 1.08 | 0.7749 |
| CD14 | Monocyte antigen CD14 | CD14 | 0.56 | 0.0033 | 1.21 | 0.1658 |
| CERU | Ceruloplasmin | CP | 0.67 | 0.0013 | 1.05 | 0.6129 |
| CFAB | Complement factor B | CFB | 0.61 | 0.0006 | 1.11 | 0.6441 |
| CO2 | Complement C2 | C2 | 0.64 | 0.0475 | 1.57 | 0.0679 |
| CO4A | Complement C4-A | C4A | 0.87 | 0.0435 | 0.94 | 0.7749 |
| CO4B | Complement C4-B | C4B | 0.73 | 0.0127 | 0.99 | 0.5526 |
| CO5 | Complement C5 | C5 | 0.77 | 0.0085 | 0.91 | 0.8776 |
| CO6 | Complement component C6 | C6 | 0.64 | 0.0013 | 0.97 | 0.8431 |
| CO8G | Complement component C8 gamma | C8G | 0.66 | 0.0137 | 1.12 | 0.4679 |
| CO9 | Complement component C9 | C9 | 0.42 | <0.0001 | 0.93 | 0.9124 |
| CRP | C-reactive protein | CRP | <0.01 | 0.0389 | 0.15 | 0.0414 |
| CXCL7 | Platelet basic protein | PPBP | 0.83 | 0.1516 | 1.53 | 0.0030 |
| FETUA | Alpha-2-HS-glycoprotein | AHSG | 0.90 | 0.3095 | 1.34 | 0.0068 |
| FHR1 | Complement factor H-related prot. 1 | CFHR1 | 0.66 | 0.0725 | 1.30 | 0.0366 |
| GPX3 | Glutathione peroxidase 3 | GPX3 | 0.92 | 0.6065 | 1.47 | 0.0453 |
| HBA | Hemoglobin subunit alpha | HBA1 | 2.02 | 0.0016 | 1.18 | 0.5824 |
| HBB | Hemoglobin subunit beta | HBB | 2.26 | 0.0005 | 1.11 | 0.6441 |
| HBD | Hemoglobin subunit delta | HBD | 4.59 | 0.0030 | 1.02 | 0.9608 |
| HEMO | Hemopexin | HPX | 0.77 | 0.0061 | 1.00 | 0.9124 |
| HGFA | Hepatocyte growth factor activator | HGFAC | 1.57 | 0.0868 | 1.74 | 0.0366 |
| HGFL | Hepatocyte growth factor-like prot. | MST1 | 1.40 | 0.4048 | 3.28 | 0.0156 |
| HPT | Haptoglobin | HP | 0.68 | 0.0014 | 1.02 | 0.7749 |
| IC1 | Plasma protease C1 inhibitor | SERPING1 | 3.36 | 0.0001 | 0.21 | 0.0030 |
| ITIH1 | Inter-alpha-trypsin inhib. heavy ch. 1 | ITIH1 | 0.77 | 0.0465 | 1.06 | 0.2099 |
| ITIH3 | Inter-alpha-trypsin inhib. heavy ch. 3 | ITIH3 | 0.45 | 0.0001 | 1.05 | 0.4414 |
| LBP | Lipopolysaccharide-binding protein | LBP | 0.42 | 0.0004 | 0.78 | 0.7084 |
| LG3BP | Galectin-3-binding protein | LGALS3BP | 0.23 | 0.0006 | 1.29 | 0.8776 |
| PGRP2 | N-acetylmuramoyl-l-alanine amidase | PGLYRP2 | 0.82 | 0.0497 | 1.15 | 0.4157 |
| PLF4 | Platelet factor 4 | PF4 | 1.00 | 0.9667 | 1.41 | 0.0366 |
| PON1 | Serum paraoxonase/arylesterase 1 | PON1 | 0.88 | 0.4606 | 1.42 | 0.0442 |
| PROP | Properdin | CFP | 1.45 | 0.0028 | 1.11 | 0.9825 |
| PROZ | Vitamin K-dependent protein Z | PROZ | 0.93 | 0.6864 | 2.08 | 0.0186 |
| S10A9 | Protein S100-A9 | S100A9 | 0.11 | 0.0054 | 0.74 | 0.2526 |
| SAA1 | Serum amyloid A-1 protein | SAA1 | 0.04 | 0.0407 | 0.49 | 0.2099 |
| SAA2 | Serum amyloid A-2 protein | SAA2 | <0.01 | 0.0389 | 0.44 | 0.3069 |
| SEPP1 | Selenoprotein P | SEPP1 | 1.72 | 0.1292 | 1.52 | 0.0186 |
| SHBG | Sex hormone-binding globulin | SHBG | 0.20 | 0.0329 | 0.67 | 0.1968 |
| THBG | Thyroxine-binding globulin | SERPINA7 | 0.70 | 0.0309 | 0.80 | 0.8088 |
| TSP1 | Thrombospondin-1 | THBS1 | 0.74 | 0.1363 | 1.49 | 0.0436 |
| VTDB | Vitamin D-binding protein | GC | 0.81 | 0.0160 | 1.24 | 0.0235 |
| VTNC | Vitronectin | VTN | 0.82 | 0.0394 | 1.15 | 0.1083 |
Showed are proteins, which abundances were different between samples from healthy controls and patients with stomach cancer (all cases), or between patients with locally advanced and metastatic cancer. Differences (ratios of the mean abundances) that passed the threshold of statistical significance (p < 0.05) are marked in italics characters