Table 3.
Prevalence of point mutations found in dhfr/dhps genes from included studies
| Authors | Year of collecting | Dhps mutations | Dhfr mutations | Quint. mutant (dhfr and dhps) | Wild | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A437G | K540E | Double mutants | N51I | C59R | S108N | Triple mutants | – | dhps | dhfr | both | |||
| 1. | Alker et al. | 2002 | 72 % | 67 % | – | >95 % | 66 % | >95 % | – | 43 % | – | – | 1 % |
| 2. | Cohuet et al. | 2003–2004 | – | – | <20 % | – | – | – | >50 % | 0.9–12.8 % | 29.4–75.6 % | 1–3.9 % | – |
| 3. | Swarthout et al. | 2004 | 0.6 % | – | 45.2 % | – | – | 3.2 % | 46.2 % | 27.1 % | 30 % | 7.6 % | 3 % |
| 4 | Taylor et al. | 2007 | – | – | 14.6 % | – | – | – | – | – | 35.1 % | – | – |
| 5. | Mobula et al. | 2008 | 93.1 % | 9.5 % | – | 97.9 % | 80.7 % | 99.1 % | – | – | – | – | – |