Figure 6.

Summary of genes identified in the screen affecting the NB5-6T lineage. The NB5-6T lineage and the four Ap neurons (red) are depicted at the center with the Ap4/FMRFa cell (green). Based upon previous studies and gene category, we grouped most of the genes identified in the screen in broadly defined categories (blue): these include epigenetic factors, spatial cues, signaling cues, NB identity, and temporal cues, as well as PcG/Hox cues. Two genes are known to specify Ap4 cell fate (red), and two genes control TGFβ/BMP retrograde signaling (brown). Genes involved in cell cycle genes, proteolysis, asymmetric cell division, and Notch signaling (green) all play roles in controlling precise proliferation of NBs and daughters. The categorization of some genes identified requires further study (purple). These are genes involved in nuclear export, RNA processing, chromosome condensation, cytokinesis, and three genes (mute, Surf6, and Pka-R1) that are not readily categorized.