Figure 8.

The contributions of standing genetic variation (light gray) and de novo mutations (dark gray) to the cumulative phenotypic response to selection $\overline{z}$ (A) and the current genetic variance (B) over time. Plots show average trajectories over 1000 replicate simulations. The red circle marks the point in time where $50\mathrm{\%}$ of the total phenotypic responses were due to de novo mutations. The inset in A shows a more detailed plot of the dynamics of $\overline{z}$ up to this point. Fixed parameters: ${\sigma }_{\mathrm{s}}^2=50$, $\mathrm{\Theta }=5$, $N=2500$, $\nu =0.001$, ${\sigma }_{\mathrm{m}}^2=\mathrm{0.05.}$