Table 5. Evidence for lineage-specific recurrent adaptive protein evolution at Nup160.

		Polymorphic			Divergent			Fisher’s exact P-value
Line		R	S	R/S	R	S	R/S
1	D. melanogaster–D. simulans pooleda	27	154	0.175	58	64	0.906	9.3 × 10−10
2	D. simulans–D.mauritiana pooled	34	168	0.202	20	4	5.000	8.2 × 10−11
3	D. simulans–D. sechellia pooled	19	107	0.178	27	20	1.350	1.1 × 10−7
4	D. sechellia–D. mauritiana pooled	19	87	0.218	12	18	0.667	0.015
5	D. melanogaster lineage	10	56	0.179	18	32	0.563	0.015
6	D. simulans clade ancestral lineage	17b	100b	0.170	24	15	1.600	4.4 × 10−8
7	D. simulans lineage	17	100	0.170	12	3	4.000	4.4 × 10−7
8	D. sechellia lineage	2	7	0.286	8	6	1.333	0.197
9	D. mauritiana lineage	34	168	0.202	1	0	—	0.172

^aD. melanogaster and D. simulans data are from Tang and Presgraves (2009).

^bFor this MK test, the D. simulans clade ancestral population is assumed to have the same numbers of nonsynonymous and synonymous polymorphisms as the extant D. simulans population sample.