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Chromatin modification and PCD regulation. H2K11 acetylation prevents H2S10 phosphorylation and chromatin condensation. Activation of Hos2 deacetylase removes the acetylation mark, allowing Ste20-dependent phosphorylation of H2S10 and PCD completion. Separate methylation marks at H3K4 and H3K79 have opposite impacts on PCD progression. Independent cyclin C–Cdk8 and Jhd2 demethylase activities reduce H3K4 methylation antagonizing Set1 activity and promoting cell death.
